PMID- 20058030
OWN - NLM
STAT- MEDLINE
DCOM- 20100511
LR  - 20220410
IS  - 1435-5922 (Electronic)
IS  - 0944-1174 (Linking)
VI  - 45
IP  - 2
DP  - 2010 Feb
TI  - Epidemiological study of gastroenteropancreatic neuroendocrine tumors in Japan.
PG  - 234-43
LID - 10.1007/s00535-009-0194-8 [doi]
AB  - BACKGROUND: There have been few epidemiological studies on gastroenteropancreatic 
      neuroendocrine tumors (GEP-NETs) in Japan. METHODS: We examined the epidemiology 
      of GEP-NETs [pancreatic endocrine tumors (PETs) and gastrointestinal 
      neuroendocrine tumors (GI-NETs)] in Japan in 2005 using a nationwide stratified 
      random sampling method. RESULTS: A total of 2,845 individuals received treatment 
      for PETs. Prevalence was estimated as 2.23/100,000 with an annual onset incidence 
      of 1.01/100,000. Non-functioning tumor (NF)-PET constituted 47.4%, followed by 
      insulinoma (38.2%) and gastrinoma (7.9%). Distant metastases were reported in 21% 
      patients with NF-PETs and occurred more frequently as tumor size increased (>2 
      cm). Multiple endocrine neoplasia type 1 (MEN-1) was detected in 10% of PETs but 
      only in 6.1% of NF-PETs. NF-PETs were detected incidentally by physical 
      examination in 24% patients. In 2005, an estimated 4,406 patients received 
      treatment for GI-NETs. Prevalence was estimated as 3.45/100,000, with an annual 
      onset incidence of 2.10/100,000. The locations of GI-NETs varied: foregut, 30.4%; 
      midgut, 9.6%; and hindgut, 60.0%. Distant metastases were observed in 6%. Lymph 
      node metastases occurred more frequently as tumor size increased (>1 cm). The 
      frequency of MEN-1 complications was 1%. Physical examination revealed GI-NETs in 
      44% patients. The frequency of symptomatic GI-NETs was 3.4%. Interestingly, 77.1% 
      of patients with foregut GI-NETs had type A gastritis. CONCLUSION: Our results 
      show there are large differences in GEP-NETs between Japan and Western nations, 
      primarily due to differences in the presence of MEN-1 in NF-PETs and the 
      location, symptomatic status, and prevalence of malignancy in GI-NETs.
FAU - Ito, Tetsuhide
AU  - Ito T
AD  - Department of Medicine and Bioregulatory Science, Graduate School of Medical 
      Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
FAU - Sasano, Hironobu
AU  - Sasano H
FAU - Tanaka, Masao
AU  - Tanaka M
FAU - Osamura, R Yoshiyuki
AU  - Osamura RY
FAU - Sasaki, Iwao
AU  - Sasaki I
FAU - Kimura, Wataru
AU  - Kimura W
FAU - Takano, Koji
AU  - Takano K
FAU - Obara, Takao
AU  - Obara T
FAU - Ishibashi, Miyuki
AU  - Ishibashi M
FAU - Nakao, Kazuwa
AU  - Nakao K
FAU - Doi, Ryuichiro
AU  - Doi R
FAU - Shimatsu, Akira
AU  - Shimatsu A
FAU - Nishida, Toshirou
AU  - Nishida T
FAU - Komoto, Izumi
AU  - Komoto I
FAU - Hirata, Yukio
AU  - Hirata Y
FAU - Nakamura, Kazuhiko
AU  - Nakamura K
FAU - Igarashi, Hisato
AU  - Igarashi H
FAU - Jensen, Robert T
AU  - Jensen RT
FAU - Wiedenmann, Bertram
AU  - Wiedenmann B
FAU - Imamura, Masayuki
AU  - Imamura M
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Gastroenterol
JT  - Journal of gastroenterology
JID - 9430794
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Data Collection
MH  - Female
MH  - Gastrointestinal Neoplasms/*epidemiology/pathology
MH  - Humans
MH  - Incidence
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Neuroendocrine Tumors/*epidemiology/pathology
MH  - Pancreatic Neoplasms/*epidemiology/pathology
MH  - Prevalence
MH  - Young Adult
EDAT- 2010/01/09 06:00
MHDA- 2010/05/12 06:00
CRDT- 2010/01/09 06:00
PHST- 2009/09/10 00:00 [received]
PHST- 2009/12/11 00:00 [accepted]
PHST- 2010/01/09 06:00 [entrez]
PHST- 2010/01/09 06:00 [pubmed]
PHST- 2010/05/12 06:00 [medline]
AID - 10.1007/s00535-009-0194-8 [doi]
PST - ppublish
SO  - J Gastroenterol. 2010 Feb;45(2):234-43. doi: 10.1007/s00535-009-0194-8.