PMID- 20060862
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20131121
IS  - 1095-8304 (Electronic)
IS  - 0195-6663 (Linking)
VI  - 54
IP  - 2
DP  - 2010 Apr
TI  - Homeostatic alterations after IL-1beta microinjection into the nucleus accumbens 
      of the rat.
PG  - 354-62
LID - 10.1016/j.appet.2010.01.001 [doi]
AB  - The present study investigates the effects of direct administration of 
      interleukin-1beta (IL-1beta) into the nucleus accumbens (NAcc) on homeostatic 
      regulation. Short- and long-term food intakes (FI), water intakes (WI) and body 
      temperature (BT) were measured before and after bilateral microinjection of 
      IL-1beta (with or without paracetamol pretreatment) into the NAcc of Wistar rats, 
      and the effects were compared with those found in vehicle treated control 
      animals. In addition, blood glucose levels, along with a glucose tolerance test 
      (GTT), and plasma concentrations of metabolic parameters, such as total 
      cholesterol, triglycerides, HDL, LDL and uric acid were determined in cytokine 
      treated and control rats. Short-term FI and WI were suppressed after 
      intraaccumbens application of IL-1beta. A significant increase of BT was also 
      observed after the cytokine microinjection. Pretreatment with paracetamol failed 
      to influence the anorexigenic, adipsogenic, and pyrogenic effects of IL-1beta. A 
      definite glucose intolerance of the cytokine treated animals and their 
      pathologically elevated blood glucose levels became obvious in the acute GTT. 
      Following IL-1beta microinjection, plasma levels of triglycerides, total 
      cholesterol and LDL were found increased. Our present findings show that the NAcc 
      is an important site of action of IL-1beta mediated processes in central 
      homeostatic regulation.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Takacs, Gabor
AU  - Takacs G
AD  - Institute of Physiology and Neurophysiology Research Group of the Hungarian 
      Academy of Sciences, Pecs University, Medical School, Szigeti str. 12, H-7624 
      Pecs, Hungary. gabor.takacs@aok.pte.hu
FAU - Papp, Szilard
AU  - Papp S
FAU - Lukats, Balazs
AU  - Lukats B
FAU - Szalay, Csaba
AU  - Szalay C
FAU - Nagy, Bernadett
AU  - Nagy B
FAU - Fotakos, Dimitrios
AU  - Fotakos D
FAU - Karadi, Zoltan
AU  - Karadi Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100111
PL  - England
TA  - Appetite
JT  - Appetite
JID - 8006808
RN  - 0 (Blood Glucose)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Lipids)
RN  - 268B43MJ25 (Uric Acid)
RN  - 362O9ITL9D (Acetaminophen)
SB  - IM
MH  - Acetaminophen/pharmacology
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Body Temperature/*drug effects/physiology
MH  - Drinking/*drug effects/physiology
MH  - Feeding Behavior/*drug effects/physiology
MH  - Homeostasis/*drug effects/physiology
MH  - Interleukin-1beta/*pharmacology
MH  - Lipid Metabolism/drug effects
MH  - Lipids/blood
MH  - Male
MH  - Microinjections
MH  - Nucleus Accumbens/*drug effects/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Uric Acid/blood
EDAT- 2010/01/12 06:00
MHDA- 2010/05/05 06:00
CRDT- 2010/01/12 06:00
PHST- 2009/09/10 00:00 [received]
PHST- 2009/12/29 00:00 [revised]
PHST- 2010/01/05 00:00 [accepted]
PHST- 2010/01/12 06:00 [entrez]
PHST- 2010/01/12 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
AID - S0195-6663(10)00019-X [pii]
AID - 10.1016/j.appet.2010.01.001 [doi]
PST - ppublish
SO  - Appetite. 2010 Apr;54(2):354-62. doi: 10.1016/j.appet.2010.01.001. Epub 2010 Jan 
      11.