PMID- 20060864
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20131121
IS  - 1095-8304 (Electronic)
IS  - 0195-6663 (Linking)
VI  - 54
IP  - 2
DP  - 2010 Apr
TI  - Serotonin delivery into the ventromedial nucleus of the hypothalamus affects 
      differently feeding pattern and body weight in obese and lean Zucker rats.
PG  - 346-53
LID - 10.1016/j.appet.2009.12.015 [doi]
AB  - AIM: To determine if central serotonin (5-HT)-induced satiety is altered in 
      obesity. METHODS: Obese and lean Zucker rats received infusion of 5-HT (5 
      microg/0.5 microl/h) or saline into the ventromedial nucleus of the hypothalamus 
      (VMN) for 2 weeks. RESULTS: In lean rats, 5-HT decreased body weight (7%) and 
      total food intake (15%) which was due to a decreased meal size during the dark 
      phase. In obese rats, a decrease of food intake was also observed in the dark 
      phase, but it was compensated by an increased food intake during the light phase, 
      resulting in no significant changes of total food intake and body weight. In 
      obese rats, meal number but not meal size was affected by 5-HT delivery. Body fat 
      content was not affected by 5-HT in obese rats, while cessation of 5-HT delivery 
      in lean rats resulted in 13% increase. CONCLUSION: Intra-VMN 5-HT in obese rats 
      did not increase meal-associated satiety as it did in lean rats, but modulated 
      hunger. These results show that the Zucker obese phenotype is characterized by 
      VMN resistance to 5-HT, which may contribute to neurobiological mechanisms of 
      increased meal size and food intake and may diminish anti-obesity effects of 
      serotonergic anorexiants.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Fetissov, Serguei O
AU  - Fetissov SO
AD  - Neuroscience Program, Surgical Metabolism and Nutrition Laboratory, Department of 
      Surgery, State University of New York Upstate Medical University, Syracuse, NY 
      13210, USA. Serguei.Fetissov@univ-rouen.fr
FAU - Meguid, Michael M
AU  - Meguid MM
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100111
PL  - England
TA  - Appetite
JT  - Appetite
JID - 8006808
RN  - 0 (Serotonin Agents)
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Adipose Tissue/metabolism
MH  - Animals
MH  - Body Composition/drug effects/physiology
MH  - Body Weight/*drug effects
MH  - Disease Models, Animal
MH  - Energy Intake/drug effects
MH  - Feeding Behavior/*drug effects/physiology
MH  - Obesity/*physiopathology
MH  - Photoperiod
MH  - Rats
MH  - Rats, Zucker
MH  - Serotonin/*pharmacology
MH  - Serotonin Agents/pharmacology
MH  - Thinness/*physiopathology
MH  - Ventromedial Hypothalamic Nucleus/*drug effects/metabolism
EDAT- 2010/01/12 06:00
MHDA- 2010/05/05 06:00
CRDT- 2010/01/12 06:00
PHST- 2009/10/01 00:00 [received]
PHST- 2009/12/10 00:00 [revised]
PHST- 2009/12/28 00:00 [accepted]
PHST- 2010/01/12 06:00 [entrez]
PHST- 2010/01/12 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
AID - S0195-6663(10)00020-6 [pii]
AID - 10.1016/j.appet.2009.12.015 [doi]
PST - ppublish
SO  - Appetite. 2010 Apr;54(2):346-53. doi: 10.1016/j.appet.2009.12.015. Epub 2010 Jan 
      11.