PMID- 20061317
OWN - NLM
STAT- MEDLINE
DCOM- 20100809
LR  - 20131121
IS  - 1460-2385 (Electronic)
IS  - 0931-0509 (Linking)
VI  - 25
IP  - 5
DP  - 2010 May
TI  - Intra-peritoneal interleukin-6 system is a potent determinant of the baseline 
      peritoneal solute transport in incident peritoneal dialysis patients.
PG  - 1639-46
LID - 10.1093/ndt/gfp670 [doi]
AB  - BACKGROUND: Interleukin-6 (IL-6) is a key player in modulating inflammation. IL-6 
      and soluble IL-6 receptor (sIL-6R) complex induces the synthesis and secretion of 
      various chemokines, adhesion molecules and angiogenic molecules. We hypothesized 
      that the baseline peritoneal solute transport rate (PSTR) early after commencing 
      peritoneal dialysis (PD) may depend largely on the IL-6/sIL-6R system. We also 
      hypothesized that the dialysate concentrations of IL-6/sIL-6R could be closely 
      related to local inflammation or angiogenesis in the peritoneal cavity. METHODS: 
      Fifty incident patients with a modified peritoneal equilibration test result 
      within 3 months after commencing PD and without a previous history of peritonitis 
      were enrolled. Clinical parameters such as age, sex, comorbid disease, body mass 
      index, residual renal function and C-reactive protein were assessed. Serum and 
      dialysate markers including CA125, IL-6, sIL-6R, monocyte chemoattractant 
      protein-1 (MCP-1), vascular endothelial growth factor (VEGF) and angiopoietin-2 
      (Ang-2) were measured and correlated with PSTR. RESULTS: Dialysate concentrations 
      of IL-6 (r = 0.576, P < 0.001), MCP-1 (r = 0.408, P = 0.003) and Ang-2 (r = 
      0.408, P = 0.003) correlated with mass transfer area coefficient for creatinine 
      (MTAC(cr)), respectively. Dialysate appearance rate (AR) of albumin correlated 
      with dialysate concentrations of CA125 (r = 0.751, P < 0.001), IL-6 (r = 0.303, P 
      = 0.039), sIL-6R (r = 0.497, P < 0.001), MCP-1 (r = 0.488, P < 0.001), VEGF (r = 
      0.443, P = 0.004) and Ang-2 (r = 0.488, P < 0.001). Neither MTAC(cr) nor AR of 
      albumin was associated with systemic markers. Multivariate analysis showed that 
      MTAC(cr) is independently associated with dialysate IL-6 and serum albumin. It 
      also showed that AR of albumin is independently predicted by dialysate sIL-6R. 
      Dialysate IL-6 correlated with dialysate concentrations of CA125 MCP-1, VEGF and 
      Ang-2. CONCLUSION: Our study from incident PD patients suggested that (i) 
      dialysate the IL-6 system is a potent determinant of baseline PSTR and (ii) 
      elevation of IL-6 in the dialysate is associated with up-regulation of 
      intra-peritoneal inflammatory and angiogenic molecules.
FAU - Oh, Kook-Hwan
AU  - Oh KH
AD  - Department of Internal Medicine, Seoul National University Hospital, Seoul, 
      Korea.
FAU - Jung, Ji Yong
AU  - Jung JY
FAU - Yoon, Myeong Ok
AU  - Yoon MO
FAU - Song, Aeran
AU  - Song A
FAU - Lee, Hajeong
AU  - Lee H
FAU - Ro, Han
AU  - Ro H
FAU - Hwang, Young-Hwan
AU  - Hwang YH
FAU - Kim, Dong Ki
AU  - Kim DK
FAU - Margetts, Peter
AU  - Margetts P
FAU - Ahn, Curie
AU  - Ahn C
LA  - eng
PT  - Journal Article
DEP - 20100108
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European 
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
RN  - 0 (Albumins)
RN  - 0 (Angiopoietin-2)
RN  - 0 (CA-125 Antigen)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Albumins/metabolism
MH  - Angiopoietin-2/blood
MH  - Biological Transport
MH  - CA-125 Antigen/blood
MH  - Chemokine CCL2/blood
MH  - Creatinine/metabolism
MH  - Female
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - *Peritoneal Dialysis
MH  - Peritoneum/*metabolism
MH  - Vascular Endothelial Growth Factor A/blood
EDAT- 2010/01/12 06:00
MHDA- 2010/08/10 06:00
CRDT- 2010/01/12 06:00
PHST- 2010/01/12 06:00 [entrez]
PHST- 2010/01/12 06:00 [pubmed]
PHST- 2010/08/10 06:00 [medline]
AID - gfp670 [pii]
AID - 10.1093/ndt/gfp670 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2010 May;25(5):1639-46. doi: 10.1093/ndt/gfp670. Epub 
      2010 Jan 8.