PMID- 20061363
OWN - NLM
STAT- MEDLINE
DCOM- 20100514
LR  - 20111117
IS  - 1460-2180 (Electronic)
IS  - 0143-3334 (Linking)
VI  - 31
IP  - 5
DP  - 2010 May
TI  - Individuals susceptible to lung adenocarcinoma defined by combined HLA-DQA1 and 
      TERT genotypes.
PG  - 834-41
LID - 10.1093/carcin/bgq003 [doi]
AB  - Adenocarcinoma (ADC) is the commonest histological type of lung cancer, and its 
      weak association with smoking indicates the necessity to identify high-risk 
      individuals for targeted screening and/or prevention. By a genome-wide 
      association study (GWAS), we identified an association of polymorphisms in the 
      6p21.31 locus containing four human leukocyte antigen (HLA) class II genes with 
      lung ADC risk. DQA1*03 of the HLA-DQA1 gene was defined as a risk allele with 
      odds ratio (OR) of 1.36 [95% confidence interval (CI) = 1.21-1.54, P = 5.3 x 
      10(-7)] by analysis of 1656 ADC cases and 1173 controls. DQA1*03 and the minor 
      allele for a polymorphism, rs2736100, in TERT, another lung cancer susceptibility 
      locus identified in recent GWASs on Europeans and Americans, were indicated to 
      independently contribute to ADC risk with per allele OR of 1.43 (95% CI = 
      1.31-1.56, P = 7.8 x 10(-16)). Individuals homozygous both for the DQA1*03 and 
      minor TERT alleles were defined as high-risk individuals with an OR of 4.76 (95% 
      CI = 2.53-9.47, P = 4.2 x 10(-7)). The present results indicated that individuals 
      susceptible to lung ADC can be defined by combined genotypes of HLA-DQA1 and 
      TERT.
FAU - Kohno, Takashi
AU  - Kohno T
AD  - Biology Division, National Cancer Center Research Institute, Tokyo 104-0045, 
      Japan.
FAU - Kunitoh, Hideo
AU  - Kunitoh H
FAU - Shimada, Yoko
AU  - Shimada Y
FAU - Shiraishi, Kouya
AU  - Shiraishi K
FAU - Ishii, Yuko
AU  - Ishii Y
FAU - Goto, Koichi
AU  - Goto K
FAU - Ohe, Yuichiro
AU  - Ohe Y
FAU - Nishiwaki, Yutaka
AU  - Nishiwaki Y
FAU - Kuchiba, Aya
AU  - Kuchiba A
FAU - Yamamoto, Seiichiro
AU  - Yamamoto S
FAU - Hirose, Hiroshi
AU  - Hirose H
FAU - Oka, Akira
AU  - Oka A
FAU - Yanagitani, Noriko
AU  - Yanagitani N
FAU - Saito, Ryusei
AU  - Saito R
FAU - Inoko, Hidetoshi
AU  - Inoko H
FAU - Yokota, Jun
AU  - Yokota J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100108
PL  - England
TA  - Carcinogenesis
JT  - Carcinogenesis
JID - 8008055
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (Receptors, Nicotinic)
RN  - 0 (nicotinic receptor subunit alpha3)
RN  - EC 2.7.7.49 (TERT protein, human)
RN  - EC 2.7.7.49 (Telomerase)
SB  - IM
MH  - Adenocarcinoma/etiology/*genetics
MH  - Aged
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ alpha-Chains
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Lung Neoplasms/etiology/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Receptors, Nicotinic/genetics
MH  - Telomerase/*genetics
EDAT- 2010/01/12 06:00
MHDA- 2010/05/15 06:00
CRDT- 2010/01/12 06:00
PHST- 2010/01/12 06:00 [entrez]
PHST- 2010/01/12 06:00 [pubmed]
PHST- 2010/05/15 06:00 [medline]
AID - bgq003 [pii]
AID - 10.1093/carcin/bgq003 [doi]
PST - ppublish
SO  - Carcinogenesis. 2010 May;31(5):834-41. doi: 10.1093/carcin/bgq003. Epub 2010 Jan 
      8.