PMID- 20062065
OWN - NLM
STAT- MEDLINE
DCOM- 20100402
LR  - 20211020
IS  - 1546-170X (Electronic)
IS  - 1078-8956 (Linking)
VI  - 16
IP  - 2
DP  - 2010 Feb
TI  - Crucial role of interleukin-7 in T helper type 17 survival and expansion in 
      autoimmune disease.
PG  - 191-7
LID - 10.1038/nm.2077 [doi]
AB  - Interleukin-7 receptor (IL-7R) is genetically associated with susceptibility to 
      multiple sclerosis. Here we describe that IL-7 is essential for survival and 
      expansion of pathogenic T helper type 17 (T(H)17) cells in experimental 
      autoimmune encephalomyelitis (EAE). IL-7 directly expanded effector T(H)17 cells 
      in EAE and human T(H)17 cells from subjects with multiple sclerosis, whereas it 
      was not required for T(H)17 differentiation. IL-7R antagonism rendered 
      differentiated T(H)17 cells susceptible to apoptosis through the inhibition of 
      Janus kinase-signal transducer and activator of transcription-5 (JAK-STAT5) 
      pathway and altered expression of the prosurvival protein Bcl-2 and the 
      proapoptotic protein Bax, leading to decreased severity of EAE. In contrast, 
      T(H)1 and regulatory T (T(reg)) cells were less susceptible to or not affected by 
      IL-7R antagonism in vivo. The selectivity was attributable to minimal expression 
      of IL-7Ralpha in T(reg) cells and correlated with a high level of Socs1 (encoding 
      suppressor of cytokine signaling-1) expression in T(H)1 cells. The study reveals 
      a unique, previously undescribed role of IL-7-IL-7R in T(H)17 cell survival and 
      expansion and has implications in the treatment of autoimmune disease.
FAU - Liu, Xuebin
AU  - Liu X
AD  - Department of Neuroimmunology, GlaxoSmithKline Research and Development Center, 
      Shanghai, China.
FAU - Leung, Stewart
AU  - Leung S
FAU - Wang, Chunxia
AU  - Wang C
FAU - Tan, Zhu
AU  - Tan Z
FAU - Wang, Ji
AU  - Wang J
FAU - Guo, Taylor B
AU  - Guo TB
FAU - Fang, Lei
AU  - Fang L
FAU - Zhao, Yonggang
AU  - Zhao Y
FAU - Wan, Bing
AU  - Wan B
FAU - Qin, Xia
AU  - Qin X
FAU - Lu, Limin
AU  - Lu L
FAU - Li, Runsheng
AU  - Li R
FAU - Pan, Heng
AU  - Pan H
FAU - Song, Mingjuan
AU  - Song M
FAU - Liu, Ailian
AU  - Liu A
FAU - Hong, Jian
AU  - Hong J
FAU - Lu, Hongtao
AU  - Lu H
FAU - Zhang, Jingwu Z
AU  - Zhang JZ
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20100110
PL  - United States
TA  - Nat Med
JT  - Nature medicine
JID - 9502015
RN  - 0 (Interleukin-7)
RN  - 0 (STAT5 Transcription Factor)
RN  - EC 2.7.10.2 (Janus Kinases)
SB  - IM
CIN - Nat Med. 2010 Feb;16(2):166-8. PMID: 20134470
RIN - Nat Med. 2013 Dec;19(12):1673. PMID: 24466584
MH  - Animals
MH  - Cell Differentiation
MH  - Encephalomyelitis, Autoimmune, Experimental/*immunology
MH  - Interleukin-7/*immunology
MH  - Janus Kinases/metabolism
MH  - Mice
MH  - Mice, Transgenic
MH  - STAT5 Transcription Factor/metabolism
MH  - T-Lymphocytes, Helper-Inducer/*cytology
EDAT- 2010/01/12 06:00
MHDA- 2010/04/03 06:00
CRDT- 2010/01/12 06:00
PHST- 2009/05/29 00:00 [received]
PHST- 2009/11/18 00:00 [accepted]
PHST- 2010/01/12 06:00 [entrez]
PHST- 2010/01/12 06:00 [pubmed]
PHST- 2010/04/03 06:00 [medline]
AID - nm.2077 [pii]
AID - 10.1038/nm.2077 [doi]
PST - ppublish
SO  - Nat Med. 2010 Feb;16(2):191-7. doi: 10.1038/nm.2077. Epub 2010 Jan 10.