PMID- 20064544
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20211028
IS  - 1872-6216 (Electronic)
IS  - 0047-6374 (Linking)
VI  - 131
IP  - 2
DP  - 2010 Feb
TI  - The impact of acute caloric restriction on the metabolic phenotype in male 
      C57BL/6 and DBA/2 mice.
PG  - 111-8
LID - 10.1016/j.mad.2009.12.008 [doi]
AB  - Caloric restriction (CR) extends healthy lifespan in many organisms. DBA/2 mice, 
      unlike C57BL/6 mice, are reported to be unresponsive to CR. To investigate 
      potential differences underlying the CR response in male DBA/2 and C57BL/6 mice, 
      we examined several metabolic parameters following acute (1-5 weeks) 30% CR. 
      Acute CR decreased body mass (BM) in both strains, with lean and fat mass 
      decreasing in proportion to BM. Resting metabolic rate (RMR) was unaltered by CR, 
      following appropriate corrections for BM differences, although RMR was higher in 
      DBA/2 compared to C57BL/6 mice. Acute CR decreased fed blood glucose levels in 
      both strains, decreased fasting blood glucose in C57BL/6 mice but increased 
      fasting levels in DBA/2 mice. Glucose tolerance improved after 1 week of CR in 
      C57BL/6 mice but improved only after 4 weeks in DBA/2 mice. Acute CR had no 
      effect on insulin levels, but lowered insulin sensitivity and decreased 
      insulin-like growth factor-1 (IGF-1) levels in both strains. DBA/2 mice were 
      hyperinsulinaemic and insulin resistant compared to C57BL/6 mice. These 
      strain-specific differences in glucose homeostatic parameters may underlie the 
      reported unresponsiveness of DBA/2 mice to CR. We also demonstrate delineation in 
      the response of insulin and IGF-1 to acute CR in mice.
CI  - 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Hempenstall, Sarah
AU  - Hempenstall S
AD  - Integrative Physiology, Institute of Biological and Environmental Sciences, 
      University of Aberdeen, Aberdeen AB24 2TZ, UK.
FAU - Picchio, Lucie
AU  - Picchio L
FAU - Mitchell, Sharon E
AU  - Mitchell SE
FAU - Speakman, John R
AU  - Speakman JR
FAU - Selman, Colin
AU  - Selman C
LA  - eng
GR  - BB/G009953/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100112
PL  - Ireland
TA  - Mech Ageing Dev
JT  - Mechanisms of ageing and development
JID - 0347227
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Blood Glucose/analysis
MH  - Body Composition
MH  - *Caloric Restriction
MH  - Fasting
MH  - Glucose/*physiology
MH  - Insulin/blood/*metabolism
MH  - Insulin Resistance
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred DBA
MH  - *Phenotype
MH  - Time Factors
EDAT- 2010/01/13 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/01/13 06:00
PHST- 2009/08/08 00:00 [received]
PHST- 2009/12/18 00:00 [revised]
PHST- 2009/12/24 00:00 [accepted]
PHST- 2010/01/13 06:00 [entrez]
PHST- 2010/01/13 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - S0047-6374(10)00003-5 [pii]
AID - 10.1016/j.mad.2009.12.008 [doi]
PST - ppublish
SO  - Mech Ageing Dev. 2010 Feb;131(2):111-8. doi: 10.1016/j.mad.2009.12.008. Epub 2010 
      Jan 12.