PMID- 20064773
OWN - NLM
STAT- MEDLINE
DCOM- 20110328
LR  - 20221207
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 118
IP  - 3
DP  - 2010 Mar
TI  - Association of low-dose exposure to persistent organic pollutants with global DNA 
      hypomethylation in healthy Koreans.
PG  - 370-4
LID - 10.1289/ehp.0901131 [doi]
AB  - BACKGROUND: Global DNA methylation levels have been reported to be inversely 
      associated with blood levels of persistent organic pollutants (POPs), xenobiotics 
      that accumulate in adipose tissue. Whether these associations extend to a 
      population with much lower concentrations of POPs is not known. OBJECTIVES: This 
      study was performed to examine whether low-dose exposure to POPs was associated 
      with global DNA hypomethylation in Koreans. METHODS: The amount of global DNA 
      hypomethylation was estimated by the percent 5-methyl-cytosine (%5-mC) in Alu and 
      LINE-1 assays in 86 apparently healthy Koreans. Among various POPs, 
      organochlorine (OC) pesticides, polychlorinated biphenyls (PCBs), and 
      polybrominated diphenylethers (PBDEs) were measured. RESULTS: Most OC pesticides 
      were inversely and significantly associated with %5-mC in the Alu assay, with 
      correlation coefficients in the range 0.2 to 0.3 after adjusting for age, sex, 
      body mass index, smoking, and alcohol. The strongest OC pesticide associations 
      with %5-mC in the Alu assay were observed with oxychlordane, trans-nonachlor, and 
      p,p -dichlorodiphenyldichloroethylene. The correlation coefficient of age with 
      %5-mC in the Alu assay was 0.24, similar to correlations of OC pesticides with 
      %5-mC in the Alu assay. Most PCBs and PBDEs showed nonsignificant inverse trends 
      with %5-mC in the Alu assay, but for some PCBs the U-shaped association was 
      significant. On the other hand, POPs were not associated with %5-mC in the LINE-1 
      assay. CONCLUSIONS: We found that low-dose exposure to POPs, in particular OC 
      pesticides, was associated with global DNA hypomethylation in apparently healthy 
      Koreans.
FAU - Kim, Keon-Yeop
AU  - Kim KY
AD  - Department of Preventative Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Korea.
FAU - Kim, Dong-Sun
AU  - Kim DS
FAU - Lee, Sung-Kook
AU  - Lee SK
FAU - Lee, In-Kyu
AU  - Lee IK
FAU - Kang, Jung-Ho
AU  - Kang JH
FAU - Chang, Yoon-Seok
AU  - Chang YS
FAU - Jacobs, David R
AU  - Jacobs DR
FAU - Steffes, Michael
AU  - Steffes M
FAU - Lee, Duk-Hee
AU  - Lee DH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091106
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Organic Chemicals)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Asian People
MH  - DNA Methylation/*drug effects
MH  - Demography
MH  - Environmental Exposure/adverse effects/*analysis
MH  - Environmental Pollutants/blood/*toxicity
MH  - Female
MH  - Halogenated Diphenyl Ethers
MH  - *Health
MH  - Humans
MH  - Hydrocarbons, Chlorinated
MH  - Korea/ethnology
MH  - Male
MH  - Middle Aged
MH  - Organic Chemicals/blood/*toxicity
MH  - Pesticides
MH  - Polychlorinated Biphenyls
MH  - Reference Values
MH  - Time Factors
PMC - PMC2854765
EDAT- 2010/01/13 06:00
MHDA- 2011/03/29 06:00
PMCR- 2010/03/01
CRDT- 2010/01/13 06:00
PHST- 2009/06/26 00:00 [received]
PHST- 2009/11/06 00:00 [accepted]
PHST- 2010/01/13 06:00 [entrez]
PHST- 2010/01/13 06:00 [pubmed]
PHST- 2011/03/29 06:00 [medline]
PHST- 2010/03/01 00:00 [pmc-release]
AID - ehp-118-370 [pii]
AID - 10.1289/ehp.0901131 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2010 Mar;118(3):370-4. doi: 10.1289/ehp.0901131. Epub 
      2009 Nov 6.