PMID- 20064776
OWN - NLM
STAT- MEDLINE
DCOM- 20100715
LR  - 20220408
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 118
IP  - 4
DP  - 2010 Apr
TI  - Persistent organic pollutant exposure leads to insulin resistance syndrome.
PG  - 465-71
LID - 10.1289/ehp.0901321 [doi]
AB  - BACKGROUND: The incidence of the insulin resistance syndrome has increased at an 
      alarming rate worldwide, creating a serious challenge to public health care in 
      the 21st century. Recently, epidemiological studies have associated the 
      prevalence of type 2 diabetes with elevated body burdens of persistent organic 
      pollutants (POPs). However, experimental evidence demonstrating a causal link 
      between POPs and the development of insulin resistance is lacking. OBJECTIVE: We 
      investigated whether exposure to POPs contributes to insulin resistance and 
      metabolic disorders. METHODS: Sprague-Dawley rats were exposed for 28 days to 
      lipophilic POPs through the consumption of a high-fat diet containing either 
      refined or crude fish oil obtained from farmed Atlantic salmon. In addition, 
      differentiated adipocytes were exposed to several POP mixtures that mimicked the 
      relative abundance of organic pollutants present in crude salmon oil. We measured 
      body weight, whole-body insulin sensitivity, POP accumulation, lipid and glucose 
      homeostasis, and gene expression and we performed microarray analysis. RESULTS: 
      Adult male rats exposed to crude, but not refined, salmon oil developed insulin 
      resistance, abdominal obesity, and hepatosteatosis. The contribution of POPs to 
      insulin resistance was confirmed in cultured adipocytes where POPs, especially 
      organochlorine pesticides, led to robust inhibition of insulin action. Moreover, 
      POPs induced down-regulation of insulin-induced gene-1 (Insig-1) and Lpin1, two 
      master regulators of lipid homeostasis. CONCLUSION: Our findings provide evidence 
      that exposure to POPs commonly present in food chains leads to insulin resistance 
      and associated metabolic disorders.
FAU - Ruzzin, Jerome
AU  - Ruzzin J
AD  - National Institute of Nutrition and Seafood Research (NIFES), Bergen, Norway. 
      jerome.ruzzin@nifes.no
FAU - Petersen, Rasmus
AU  - Petersen R
FAU - Meugnier, Emmanuelle
AU  - Meugnier E
FAU - Madsen, Lise
AU  - Madsen L
FAU - Lock, Erik-Jan
AU  - Lock EJ
FAU - Lillefosse, Haldis
AU  - Lillefosse H
FAU - Ma, Tao
AU  - Ma T
FAU - Pesenti, Sandra
AU  - Pesenti S
FAU - Sonne, Si Brask
AU  - Sonne SB
FAU - Marstrand, Troels Torben
AU  - Marstrand TT
FAU - Malde, Marian Kjellevold
AU  - Malde MK
FAU - Du, Zhen-Yu
AU  - Du ZY
FAU - Chavey, Carine
AU  - Chavey C
FAU - Fajas, Lluis
AU  - Fajas L
FAU - Lundebye, Anne-Katrine
AU  - Lundebye AK
FAU - Brand, Christian Lehn
AU  - Brand CL
FAU - Vidal, Hubert
AU  - Vidal H
FAU - Kristiansen, Karsten
AU  - Kristiansen K
FAU - Froyland, Livar
AU  - Froyland L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091119
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
CIN - Environ Health Perspect. 2010 Apr;118(4):A173. PMID: 20359985
MH  - 3T3-L1 Cells
MH  - Animals
MH  - Carbohydrate Metabolism/drug effects
MH  - Environmental Pollutants/*toxicity
MH  - Glucose/metabolism
MH  - Glucose Clamp Technique
MH  - Hydrocarbons, Chlorinated/toxicity
MH  - *Insulin Resistance
MH  - Lipid Metabolism/drug effects
MH  - Male
MH  - Metabolic Syndrome/chemically induced/metabolism
MH  - Mice
MH  - Oligonucleotide Array Sequence Analysis
MH  - Pesticides/toxicity
MH  - Polymerase Chain Reaction
MH  - Rats
MH  - Rats, Sprague-Dawley
PMC - PMC2854721
EDAT- 2010/01/13 06:00
MHDA- 2010/07/16 06:00
PMCR- 2010/04/01
CRDT- 2010/01/13 06:00
PHST- 2009/08/11 00:00 [received]
PHST- 2009/11/19 00:00 [accepted]
PHST- 2010/01/13 06:00 [entrez]
PHST- 2010/01/13 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
PHST- 2010/04/01 00:00 [pmc-release]
AID - ehp-118-465 [pii]
AID - 10.1289/ehp.0901321 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2010 Apr;118(4):465-71. doi: 10.1289/ehp.0901321. Epub 
      2009 Nov 19.