PMID- 20065980
OWN - NLM
STAT- MEDLINE
DCOM- 20110421
LR  - 20191210
IS  - 1476-5624 (Electronic)
IS  - 1362-4393 (Linking)
VI  - 48
IP  - 8
DP  - 2010 Aug
TI  - Relevance of the diagnosis traumatic cervical Brown-Sequard-plus syndrome: an 
      analysis based on the neurological and functional recovery in a prospective 
      cohort of 148 patients.
PG  - 614-8
LID - 10.1038/sc.2009.189 [doi]
AB  - STUDY DESIGN: Prospective multi-center cohort study. OBJECTIVES: To compare the 
      neurological and functional recovery between tetraplegic Brown-Sequard-plus 
      syndrome (BSPS) and incomplete tetraplegia (non-BSPS). SETTING: European 
      Multicenter Study of Human Spinal Cord Injury (EM-SCI). METHODS: BSPS was defined 
      as a traumatic incomplete spinal cord injury (SCI) with ipsilateral weakness and 
      contralateral loss of pinprick sensation at neurologic levels C2-T1. Acute (0-15 
      days) and chronic phase (6 or 12 months) were assessed for the American Spinal 
      Injury Association (ASIA) sensory scores, upper extremity motor scores and lower 
      extremity motor scores. Furthermore, chronic phase scores of all Spinal Cord 
      Independence Measure (SCIM) II items were analyzed. Differences in neurological 
      and functional outcome between BSPS patients and non-BSPS patients were 
      calculated using Student's t-tests and Wilcoxon signed rank tests. RESULTS: Out 
      of 148 tetraplegic patients, 30 were diagnosed with BSPS. Patients with an ASIA 
      impairment scale (AIS) B were significantly (P<0.001) more identified in non-BSPS 
      patients (25%) compared with BSPS patients (3%), respectively. After 12 months, 
      the median scores for sphincter management of the bladder for both BSPS and 
      non-BSPS patients were 15. Both 25 and 75% quartile median scores were 15 for 
      BSPS patients and 12 and 15 for non-BSPS patients (P<0.02). Except for the 
      difference in bladder function, no significant differences were identified in 
      other SCIM II subitems and ASIA motor or sensory scores between BSPS and non-BSPS 
      patients when stratified for injury severity by excluding AIS B patients. 
      CONCLUSION: Compared with incomplete tetraplegic patients, patients with cervical 
      BSPS have a similar neurological and functional recovery when matched for the 
      AIS.
FAU - Pouw, M H
AU  - Pouw MH
AD  - Department of Orthopedic Surgery, Spine Unit, Radboud University Nijmegen Medical 
      Centre, Nijmegen, The Netherlands. Martinpouw@yahoo.com
FAU - van de Meent, H
AU  - van de Meent H
FAU - van Middendorp, J J
AU  - van Middendorp JJ
FAU - Hirschfeld, S
AU  - Hirschfeld S
FAU - Thietje, R
AU  - Thietje R
FAU - van Kampen, A
AU  - van Kampen A
CN  - EM-SCI study Group
FAU - Hosman, A J F
AU  - Hosman AJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20100112
PL  - England
TA  - Spinal Cord
JT  - Spinal cord
JID - 9609749
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brown-Sequard Syndrome/diagnosis/epidemiology/*physiopathology
MH  - Cohort Studies
MH  - *Disability Evaluation
MH  - Europe/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neurologic Examination/methods
MH  - Outcome Assessment, Health Care/methods
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Recovery of Function/*physiology
MH  - Severity of Illness Index
MH  - Spinal Cord Injuries/diagnosis/epidemiology/*physiopathology
MH  - Young Adult
EDAT- 2010/01/13 06:00
MHDA- 2011/04/22 06:00
CRDT- 2010/01/13 06:00
PHST- 2010/01/13 06:00 [entrez]
PHST- 2010/01/13 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - sc2009189 [pii]
AID - 10.1038/sc.2009.189 [doi]
PST - ppublish
SO  - Spinal Cord. 2010 Aug;48(8):614-8. doi: 10.1038/sc.2009.189. Epub 2010 Jan 12.