PMID- 20066403
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20211020
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 208
IP  - 4
DP  - 2010 Mar
TI  - Effects of repeated MDMA administration on the motivation for palatable food and 
      extinction of operant responding in mice.
PG  - 563-73
LID - 10.1007/s00213-009-1750-x [doi]
AB  - RATIONALE: Repeated administration of 3,4-methylenedioxymethamphetamine (MDMA) 
      produces mainly dopaminergic neurotoxicity in mice. However, the consequences of 
      this exposure on the behavioural responses related to natural reinforcing stimuli 
      are still largely unknown. OBJECTIVES: We examined whether repeated treatment 
      with neurotoxic and non-neurotoxic doses of MDMA could exert acute and 
      long-lasting effects on the motivation of mice to obtain a highly palatable food 
      and on the extinction and reinstatement of food-seeking behaviour. Food-deprived 
      mice were first trained to acquire stable responding on fixed ratio (FR) 
      schedules of reinforcement and then treated twice daily with saline, 3 or 30 
      mg/kg MDMA during four consecutive days. RESULTS: The high dose of MDMA impaired 
      instrumental responding on the first and third day of treatment, whilst no 
      residual effects were apparent on FR5 responding at any of the doses studied 24 h 
      after treatment withdrawal. Breaking points were decreased in mice treated with 
      both doses of MDMA. This decrease in motivation for palatable food was not due to 
      unspecific locomotor or coordination deficits. A resistance to extinction was 
      observed only with the highest dose of MDMA, whilst all mice showed similar 
      reinstatement of palatable food-seeking behaviour irrespective of previous 
      treatment. Autoradiography of [3H]-mazindol binding revealed a decrease in 
      striatal dopamine transporter binding only in mice treated with the highest dose 
      of MDMA. CONCLUSIONS: This study demonstrates that repeated treatment with MDMA 
      decreases the incentive motivation for a palatable food reward and that 
      long-lasting MDMA-induced dopaminergic neurotoxicity increases the resistance to 
      extinction of responding in the absence of reward.
FAU - Plaza-Zabala, Ainhoa
AU  - Plaza-Zabala A
AD  - Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la 
      Salut, Universitat Pompeu Fabra, Calle Dr Aiguader 88, 08003 Barcelona, Spain.
FAU - Vinals, Xavier
AU  - Vinals X
FAU - Maldonado, Rafael
AU  - Maldonado R
FAU - Robledo, Patricia
AU  - Robledo P
LA  - eng
GR  - (#5 R01 DA016768/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Dopamine Plasma Membrane Transport Proteins)
RN  - 10028-17-8 (Tritium)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Conditioning, Operant/*drug effects
MH  - Corpus Striatum/diagnostic imaging/drug effects/metabolism
MH  - Dopamine Plasma Membrane Transport Proteins/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Extinction, Psychological/*drug effects
MH  - Food
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Motivation/*drug effects
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Psychomotor Performance/drug effects
MH  - Radioligand Assay/methods
MH  - Radionuclide Imaging
MH  - Reinforcement Schedule
MH  - Reward
MH  - Rotarod Performance Test/methods
MH  - Tritium
EDAT- 2010/01/13 06:00
MHDA- 2011/06/22 06:00
CRDT- 2010/01/13 06:00
PHST- 2009/06/16 00:00 [received]
PHST- 2009/11/30 00:00 [accepted]
PHST- 2010/01/13 06:00 [entrez]
PHST- 2010/01/13 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
AID - 10.1007/s00213-009-1750-x [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2010 Mar;208(4):563-73. doi: 
      10.1007/s00213-009-1750-x.