PMID- 20066812 OWN - NLM STAT- MEDLINE DCOM- 20100301 LR - 20100113 IS - 0035-6484 (Print) IS - 0035-6484 (Linking) VI - 44 IP - 2 DP - 2009 Mar-Apr TI - [Functional outcome in schizophrenia: a comparative cross-sectional study on first versus second generation antipsychotics]. PG - 110-6 AB - AIM: The purpose of this study was to compare outpatients with stable schizophrenia who were treated with either first or second generation antipsychotics in terms of executive functions, social functioning and quality of life. METHODS: One-hundred and sixty-eight consecutive outpatients with stable schizophrenia were enrolled in a cross-sectional study. At the time of assessment all patients were receiving antipsychotic medication with first (FGAs) or second generation antipsychotics (SGAs). Executive functions were evaluated by the Wisconsin Card Sorting Test (WCST). We adopted the Global Assessment of Functioning (GAF), in order to assess psychological, social and occupational functioning, and the Quality of Life Scale (QLS), to evaluate patients' quality of life. The one-way analysis of variance (one-way ANOVA) was used to compare the two treatment groups with respect to all variables. RESULTS: Sixty-seven patients (40%) were on treatment with FGAs, while 101 patients (60%) were treated with SGAs. Patients treated with SGAs showed better results at WCST, in particular a significantly higher number of completed categories (p=0.009) and a lower percentage of perseverative errors (p=0.001). The subpopulation on SGAs treatment had significantly higher scores at the GAF scale (p=0.004) and at subscale of the QLS evaluating the instrumental role of patients (p=0.043). DISCUSSION: The results of our study suggest that patients treated with SGAs present better outcomes in terms of neurocognition, social functioning and working skills. FAU - Montemagni, Cristiana AU - Montemagni C AD - Dipartimento di Neuroscienze, Sezione di Psichiatria, Universita di Torino. FAU - Birindelli, Nadia AU - Birindelli N FAU - Castagna, Filomena AU - Castagna F FAU - Mingrone, Cinzia AU - Mingrone C FAU - Sigaudo, Monica AU - Sigaudo M FAU - Zappia, Serena AU - Zappia S FAU - Rocca, Paola AU - Rocca P LA - ita PT - Comparative Study PT - English Abstract PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't TT - Esito funzionale nella schizofrenia: uno studio trasversale di confronto tra antipsicotici di prima e di seconda generazione. PL - Italy TA - Riv Psichiatr JT - Rivista di psichiatria JID - 0425672 RN - 0 (Antipsychotic Agents) SB - IM MH - Adult MH - Antipsychotic Agents/*classification/*therapeutic use MH - Cross-Sectional Studies MH - Female MH - Humans MH - Male MH - Schizophrenia/*drug therapy EDAT- 2010/01/14 06:00 MHDA- 2010/03/02 06:00 CRDT- 2010/01/14 06:00 PHST- 2010/01/14 06:00 [entrez] PHST- 2010/01/14 06:00 [pubmed] PHST- 2010/03/02 06:00 [medline] PST - ppublish SO - Riv Psichiatr. 2009 Mar-Apr;44(2):110-6.