PMID- 20067106
OWN - NLM
STAT- MEDLINE
DCOM- 20110630
LR  - 20131121
IS  - 1672-173X (Print)
IS  - 1672-173X (Linking)
VI  - 40
IP  - 6
DP  - 2009 Nov
TI  - [Neuron apoptosis induced by 3,4-methylenedioxy methamphetamine and expression of 
      apoptosis-related factors in rat brain].
PG  - 1000-2, 1037
AB  - OBJECTIVE: To study the neuron apoptosis induced by i.p 3,4-methylenedioxy 
      methamphetamine (MDMA) and the expression of apoptosis-related factors in rat 
      brain. METHODS: Twenty rats were divided into 4 groups. In group A, the rats were 
      injected intraperitoneally with single dosage of saline, while the rats of group 
      B, C, D were injected i.p with MDMA in different regimen, which were 20 mg/kg, 
      single injection in group B, 20 mg/ kg twice a day (8 am and 8 pm), for 2 day in 
      group C, as well as 20 mg/kg, twice a day (8 am and 8 pm) for 4 days. Neuron 
      apoptosis were measured by TUNEL, and the expression of Caspase-3 and CytC were 
      detected by immunohistochemistry. RESULTS: Compared with saline group, apoptosis 
      neurons were detected at the related brain regions (such as frontal cortex, 
      hippocampus and striatum) of the rats in MDMA treated groups; Expression of 
      Caspase-3 and CytC was observed at different level. Compared with group B, the 
      number of apoptosis neurons of group C and D increased, and also the 
      apoptosis-related factors in the brain tissue increased (P < 0.05). CONCLUSION: 
      MDMA could induce neurons apoptosis and the expression of apoptosis-related 
      factors such as Caspase-3 and CytC in rat brain.
FAU - Wang, Xue
AU  - Wang X
AD  - Insitute of Postgraduate, West China Hospital, Sichuan University, Chengdu 
      610041, China. zwangxue73@yahoo.com.cn
FAU - Zhu, San-Ping
AU  - Zhu SP
FAU - Kuang, Wei-Hong
AU  - Kuang WH
FAU - Li, Jing
AU  - Li J
FAU - Sun, Xiao
AU  - Sun X
FAU - Huang, Ming-Sheng
AU  - Huang MS
FAU - Sun, Xue-Li
AU  - Sun XL
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Sichuan Da Xue Xue Bao Yi Xue Ban
JT  - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical 
      science edition
JID - 101162609
RN  - 0 (Hallucinogens)
RN  - 9007-43-6 (Cytochromes c)
RN  - EC 3.4.22.- (Casp3 protein, rat)
RN  - EC 3.4.22.- (Caspase 3)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Apoptosis/*drug effects
MH  - Brain/*metabolism/pathology
MH  - Caspase 3/metabolism
MH  - Cytochromes c/metabolism
MH  - Hallucinogens/toxicity
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Neurons/*pathology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2010/01/14 06:00
MHDA- 2011/07/01 06:00
CRDT- 2010/01/14 06:00
PHST- 2010/01/14 06:00 [entrez]
PHST- 2010/01/14 06:00 [pubmed]
PHST- 2011/07/01 06:00 [medline]
PST - ppublish
SO  - Sichuan Da Xue Xue Bao Yi Xue Ban. 2009 Nov;40(6):1000-2, 1037.