PMID- 20067598
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20211020
IS  - 1478-6362 (Electronic)
IS  - 1478-6354 (Print)
IS  - 1478-6354 (Linking)
VI  - 11
IP  - 6
DP  - 2009
TI  - The 'RASor's' edge: Ras proteins and matrix destruction in arthritis.
PG  - 136
LID - 10.1186/ar2840 [doi]
AB  - The shared characteristics of rheumatoid arthritis (RA) and cancer, particularly 
      their unchecked growth and invasive behaviors, have been apparent for some time. 
      However, the molecular mechanisms underlying these similarities are not clear. In 
      a recent issue of Arthritis Research & Therapy, Abreu and colleagues link a 
      well-studied oncogene, Ras, with expression of matrix metalloproteinase-3 (MMP-3) 
      in RA. Their study correlates expression of the Ras guanine nucleotide exchange 
      factor RasGRF1 with MMP-3 expression in RA synovium. They elucidate a potential 
      mechanism of regulation of MMP-3 expression in RA, suggesting a potential target 
      for RA treatment.
FAU - Schmucker, Adam C
AU  - Schmucker AC
FAU - Brinckerhoff, Constance E
AU  - Brinckerhoff CE
LA  - eng
PT  - Editorial
DEP - 20091211
PL  - England
TA  - Arthritis Res Ther
JT  - Arthritis research & therapy
JID - 101154438
RN  - 0 (ras-GRF1)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Arthritis, Rheumatoid/*metabolism/*pathology
MH  - Humans
MH  - Matrix Metalloproteinase 3/*metabolism
MH  - ras-GRF1/*metabolism
PMC - PMC3003537
EDAT- 2010/01/14 06:00
MHDA- 2010/05/21 06:00
PMCR- 2009/12/11
CRDT- 2010/01/14 06:00
PHST- 2010/01/14 06:00 [entrez]
PHST- 2010/01/14 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
PHST- 2009/12/11 00:00 [pmc-release]
AID - ar2840 [pii]
AID - 10.1186/ar2840 [doi]
PST - ppublish
SO  - Arthritis Res Ther. 2009;11(6):136. doi: 10.1186/ar2840. Epub 2009 Dec 11.