PMID- 20067905
OWN - NLM
STAT- MEDLINE
DCOM- 20100809
LR  - 20211020
IS  - 1460-2385 (Electronic)
IS  - 0931-0509 (Print)
IS  - 0931-0509 (Linking)
VI  - 25
IP  - 5
DP  - 2010 May
TI  - Glomerulonephritis after hematopoietic cell transplantation: IgA nephropathy with 
      increased excretion of galactose-deficient IgA1.
PG  - 1708-13
LID - 10.1093/ndt/gfp693 [doi]
AB  - We report the development of IgA nephropathy (IgAN) following full myeloablative 
      allogeneic hematopoietic cell transplantation in two patients with human 
      leukocyte antigen (HLA) matched sibling donors, unrelated to active or chronic 
      graft-versus-host disease. Both recipients had elevated urinary levels of 
      galactose-deficient IgA1, and one donor-recipient pair had elevated serum levels 
      of galactose-deficient IgA1. We propose that IgAN developed after bone marrow 
      transplantation due to a non-graft-versus-host-disease-related multi-hit process 
      associated with glomerular deposition of galactose-deficient IgA1. These two 
      cases provide unique insight into the kinetics of overproduction of 
      galactose-deficient IgA1 and its glomerular deposition and consequential renal 
      injury in IgAN.
FAU - Hu, Susie L
AU  - Hu SL
AD  - Division of Kidney Disease and Hypertension, Department of Medicine, Brown 
      University, Warren Alpert Medical School, Providence, RI, USA. Shu@Lifespan.org
FAU - Colvin, Gerald A
AU  - Colvin GA
FAU - Rifai, Abdalla
AU  - Rifai A
FAU - Suzuki, Hitoshi
AU  - Suzuki H
FAU - Novak, Jan
AU  - Novak J
FAU - Esparza, Alfredo
AU  - Esparza A
FAU - Farooqi, Shahida
AU  - Farooqi S
FAU - Julian, Bruce A
AU  - Julian BA
LA  - eng
GR  - DK082753/DK/NIDDK NIH HHS/United States
GR  - R21 DK075868/DK/NIDDK NIH HHS/United States
GR  - DK080301/DK/NIDDK NIH HHS/United States
GR  - DK077279/DK/NIDDK NIH HHS/United States
GR  - R21 DK080301/DK/NIDDK NIH HHS/United States
GR  - R01 DK078244/DK/NIDDK NIH HHS/United States
GR  - DK071802/DK/NIDDK NIH HHS/United States
GR  - R01 DK071802/DK/NIDDK NIH HHS/United States
GR  - R01 DK082753/DK/NIDDK NIH HHS/United States
GR  - DK078244/DK/NIDDK NIH HHS/United States
GR  - DK075868/DK/NIDDK NIH HHS/United States
GR  - R56 DK078244/DK/NIDDK NIH HHS/United States
GR  - R21 DK077279/DK/NIDDK NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100112
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European 
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
RN  - 0 (Immunoglobulin A)
RN  - X2RN3Q8DNE (Galactose)
SB  - IM
MH  - Adult
MH  - Galactose/*deficiency
MH  - Glomerulonephritis/*etiology/pathology
MH  - Glomerulonephritis, IGA/*etiology/pathology
MH  - Graft vs Host Disease/etiology
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Humans
MH  - Immunoglobulin A/*metabolism
MH  - Kidney/pathology
MH  - Male
MH  - Middle Aged
PMC - PMC2910332
EDAT- 2010/01/14 06:00
MHDA- 2010/08/10 06:00
PMCR- 2011/05/01
CRDT- 2010/01/14 06:00
PHST- 2010/01/14 06:00 [entrez]
PHST- 2010/01/14 06:00 [pubmed]
PHST- 2010/08/10 06:00 [medline]
PHST- 2011/05/01 00:00 [pmc-release]
AID - gfp693 [pii]
AID - 10.1093/ndt/gfp693 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2010 May;25(5):1708-13. doi: 10.1093/ndt/gfp693. Epub 
      2010 Jan 12.