PMID- 20068507
OWN - NLM
STAT- MEDLINE
DCOM- 20100429
LR  - 20151119
IS  - 1534-6080 (Electronic)
IS  - 0041-1337 (Linking)
VI  - 89
IP  - 7
DP  - 2010 Apr 15
TI  - Psychological predictors of mortality in heart transplanted patients: a 
      prospective, 6-year follow-up study.
PG  - 879-86
LID - 10.1097/TP.0b013e3181ca9078 [doi]
AB  - BACKGROUND: Some reports suggest a link between poor psychological adjustment to 
      heart transplantation and an increased risk of subsequent adverse clinical 
      outcome. Despite its prognostic and therapeutic implications, this issue is still 
      lacking adequate empirical studies. We prospectively tested the predictive value 
      of a complete set of psychiatric and psychological variables, collected with both 
      self-rating and observer-based instruments at midterm after heart 
      transplantation, on the subsequent 6-year survival status. METHODS: Ninety-five 
      heart transplanted patients underwent the structured clinical interview for 
      Diagnostic and Statistical Manual of Mental Disorders-4th Edition and the 
      structured interview for Diagnostic Criteria for Psychosomatic Research and 
      filled three questionnaires assessing the dimensions of psychological distress, 
      quality of life, and psychological well-being. Demographic characteristics and 
      several clinical parameters were also collected. A 6-year follow-up survival was 
      performed. RESULTS: Analyses of survival showed that hostility, depression, 
      purpose in life, the occurrence of at least one cardiac event, chronic renal 
      insufficiency, diabetes, number of drug prescriptions, a New York Heart 
      Association (NYHA) class more than or equal to II, and ischemic origin of the 
      cardiopathy significantly predicted subsequent survival duration. When 
      multivariate analyses were performed, high levels of hostility and the presence 
      of diabetes resulted the independent predictors of survival status. CONCLUSIONS: 
      These findings point out the predictive role of specific components of 
      psychological adjustment to heart transplantation and pose the basis for the 
      evaluation of whether the provision of pharmacologic and psychotherapeutic 
      interventions, aimed at reducing the empirically identified psychological risk 
      factors, may result in a better long-term outcome.
FAU - Sirri, Laura
AU  - Sirri L
AD  - Department of Psychology, University of Bologna, Bologna, Italy. 
      laurasirri@libero.it
FAU - Potena, Luciano
AU  - Potena L
FAU - Masetti, Marco
AU  - Masetti M
FAU - Tossani, Eliana
AU  - Tossani E
FAU - Magelli, Carlo
AU  - Magelli C
FAU - Grandi, Silvana
AU  - Grandi S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Aged
MH  - Diabetes Mellitus/chemically induced/mortality
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Transplantation/*mortality/*psychology
MH  - *Hostility
MH  - Humans
MH  - Immunosuppressive Agents/adverse effects
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - *Mental Health
MH  - Middle Aged
MH  - Odds Ratio
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Psychiatric Status Rating Scales
MH  - Psychometrics
MH  - Quality of Life
MH  - Risk Assessment
MH  - Risk Factors
MH  - Stress, Psychological/mortality
MH  - Surveys and Questionnaires
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2010/01/14 06:00
MHDA- 2010/04/30 06:00
CRDT- 2010/01/14 06:00
PHST- 2010/01/14 06:00 [entrez]
PHST- 2010/01/14 06:00 [pubmed]
PHST- 2010/04/30 06:00 [medline]
AID - 10.1097/TP.0b013e3181ca9078 [doi]
PST - ppublish
SO  - Transplantation. 2010 Apr 15;89(7):879-86. doi: 10.1097/TP.0b013e3181ca9078.