PMID- 20069393
OWN - NLM
STAT- MEDLINE
DCOM- 20110802
LR  - 20211020
IS  - 1559-131X (Electronic)
IS  - 1357-0560 (Linking)
VI  - 28
IP  - 1
DP  - 2011 Mar
TI  - HLA-A and breast cancer in West Peninsular Malaysia.
PG  - 51-6
LID - 10.1007/s12032-009-9414-6 [doi]
AB  - Breast cancer is the most common malignancy among females in Malaysia. Attempts 
      have been made to investigate the association between breast cancer and human 
      leukocyte antigen (HLA) types. However, data from those previous studies are 
      highly variable. The aim of this study is to investigate the association between 
      HLA-A types and clinicopathological factors in breast cancer. The frequencies of 
      HLA-A type in 59 female patients with infiltrating ductal of the breast were 
      determined by polymerase chain reaction method. HLA-A2/A30 and A2/A31 haplotype 
      (5.1%; P = 0.045) as well as HLA-A30 (5.1%, P = 0.045) and A31 (6.8%; P = 0.020) 
      allele were significant higher in the patients than controls (0%). HLA-A24 allele 
      was negatively related to lymph node metastasis (r = -0.316; P = 0.021) whereas, 
      A26 (r = -0.430; P = 0.001) and A36 (r = -0.430; P = 0.001) alleles were 
      negatively correlated to distant metastasis in breast cancer. Negative 
      correlations between HLA-A26/A36 (r = -0.430; P = 0.001), A2/A11 (r = -0.276; P = 
      0.044), A24/A34 (r = -0.430; P = 0.001) haplotypes and distant metastasis were 
      identified. Interestingly, Her2 expression in breast carcinoma was negatively 
      correlated to A11/24 haplotypes (r = -0.294; P = 0.034) but positively correlated 
      to homozygous HLA-A24 (r = 0.396; P = 0.040). In conclusion, HLA-A2, -A30 and A31 
      were associated with breast cancer.
FAU - Leong, Pooi Pooi
AU  - Leong PP
AD  - Department of Pathology, Faculty of Medicine and Health Sciences, University 
      Putra Malaysia, 43400 Selangor, Malaysia.
FAU - Muhammad, Rohaizak
AU  - Muhammad R
FAU - Ibrahim, Naqiyah
AU  - Ibrahim N
FAU - Cheong, Soon Keng
AU  - Cheong SK
FAU - Seow, Heng Fong
AU  - Seow HF
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100113
PL  - United States
TA  - Med Oncol
JT  - Medical oncology (Northwood, London, England)
JID - 9435512
RN  - 0 (HLA-A Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Breast/pathology
MH  - Breast Neoplasms/genetics/*metabolism
MH  - Carcinoma, Ductal, Breast/genetics/*metabolism
MH  - Case-Control Studies
MH  - Female
MH  - HLA-A Antigens/genetics/*metabolism
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Malaysia
MH  - Middle Aged
EDAT- 2010/01/14 06:00
MHDA- 2011/08/04 06:00
CRDT- 2010/01/14 06:00
PHST- 2009/11/18 00:00 [received]
PHST- 2009/12/30 00:00 [accepted]
PHST- 2010/01/14 06:00 [entrez]
PHST- 2010/01/14 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - 10.1007/s12032-009-9414-6 [doi]
PST - ppublish
SO  - Med Oncol. 2011 Mar;28(1):51-6. doi: 10.1007/s12032-009-9414-6. Epub 2010 Jan 13.