PMID- 20071447
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20101118
IS  - 1569-9285 (Electronic)
IS  - 1569-9285 (Linking)
VI  - 10
IP  - 4
DP  - 2010 Apr
TI  - Surgical ventricular reconstruction with different myocardial protection 
      strategies. A propensity matched analysis.
PG  - 530-4
LID - 10.1510/icvts.2009.222919 [doi]
AB  - The aim of this study is to compare outcomes of patients undergoing surgical 
      ventricular reconstruction (SVR) with normothermic cardiopulmonary bypass (CPB) 
      and beating heart or hypothermic CPB and cardioplegic arrest. Between 2001 and 
      2008, 588 patients underwent SVR. A propensity score matching was performed and 
      91 matched pairs were created: group 1 (G1) operated with normothermic CPB and 
      beating-heart technique, and group 2 (G2) operated with hypothermic CPB and 
      cardioplegic arrest. Mean age was 62+/-9 years in G1 and 63+/-10 years in G2 [not 
      significant (NS)]. Average follow-up was 42.7+/-26 months (range 1-72). Major 
      cardiac and cerebro-vascular events (MACCE) were assessed. Thirty-day mortality 
      was 4% in G1 and 5% in G2 (NS). Kaplan-Meier survival at six years was 79+/-4% 
      and 72+/-9% (NS) and freedom from MACCE was 82+/-4% and 83+/-7% in G1 and G2, 
      respectively (NS). Left ventricular volume reduction, ejection fraction and New 
      York Heart Association (NYHA) class improvement were significant in the overall 
      population; no significant differences were found between groups. The following 
      independent risk factors for cardiac death were identified: mitral valve 
      regurgitation, surgery <3 months from myocardial infarction, NYHA class III-IV. 
      This study showed that outcomes following SVR are not affected by myocardial 
      protection strategies neither in cardiac function and clinical status nor in 
      survival.
FAU - D'Onofrio, Augusto
AU  - D'Onofrio A
AD  - Division of Cardiac Surgery, San Bortolo Hospital, Viale Rodolfi 37, 36100 
      Vicenza, Italy. adonofrio@hotmail.it
FAU - Cugola, Diego
AU  - Cugola D
FAU - Bolgan, Irene
AU  - Bolgan I
FAU - Menicanti, Lorenzo
AU  - Menicanti L
FAU - Fabbri, Alessandro
AU  - Fabbri A
FAU - Di Donato, Marisa
AU  - Di Donato M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
DEP - 20100113
PL  - England
TA  - Interact Cardiovasc Thorac Surg
JT  - Interactive cardiovascular and thoracic surgery
JID - 101158399
SB  - IM
MH  - Aged
MH  - *Cardiac Surgical Procedures/adverse effects/mortality
MH  - Cardiomyopathy, Dilated/mortality/physiopathology/*surgery
MH  - *Cardiopulmonary Bypass/adverse effects/mortality
MH  - Cerebrovascular Disorders/etiology
MH  - Chi-Square Distribution
MH  - Female
MH  - *Heart Arrest, Induced/adverse effects/mortality
MH  - Heart Diseases/etiology
MH  - Heart Ventricles/physiopathology/*surgery
MH  - Humans
MH  - *Hypothermia, Induced/adverse effects/mortality
MH  - Italy/epidemiology
MH  - Kaplan-Meier Estimate
MH  - Logistic Models
MH  - Male
MH  - Matched-Pair Analysis
MH  - Middle Aged
MH  - Propensity Score
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2010/01/15 06:00
MHDA- 2010/06/11 06:00
CRDT- 2010/01/15 06:00
PHST- 2010/01/15 06:00 [entrez]
PHST- 2010/01/15 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - icvts.2009.222919 [pii]
AID - 10.1510/icvts.2009.222919 [doi]
PST - ppublish
SO  - Interact Cardiovasc Thorac Surg. 2010 Apr;10(4):530-4. doi: 
      10.1510/icvts.2009.222919. Epub 2010 Jan 13.