PMID- 20071584
OWN - NLM
STAT- MEDLINE
DCOM- 20100402
LR  - 20211020
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Print)
IS  - 0022-538X (Linking)
VI  - 84
IP  - 6
DP  - 2010 Mar
TI  - Caspase 9 is essential for herpes simplex virus type 2-induced apoptosis in T 
      cells.
PG  - 3116-20
LID - 10.1128/JVI.01726-09 [doi]
AB  - Herpes simplex virus type 2 (HSV-2) induces apoptosis in T cells by a 
      caspase-dependent mechanism. Apoptosis can occur via extrinsic (death receptor) 
      and/or intrinsic (mitochondrial) pathways. Here, we show that the initiator 
      caspase for the intrinsic pathway is activated in T cells following HSV-2 
      exposure. To determine the respective contributions of intrinsic and extrinsic 
      pathways, we assessed apoptosis in Jurkat cells that are deficient in caspase 8 
      or Fas-associating protein with death domain (FADD) for the extrinsic pathway and 
      in cells deficient in caspase 9 for the intrinsic pathway. Our results indicate 
      HSV-2-induced apoptosis in T cells occurs via the intrinsic pathway.
FAU - Vanden Oever, Michael J
AU  - Vanden Oever MJ
AD  - Department of Pediatrics and Center for Infectious Diseases and Microbiology 
      Translational Research, University of Minnesota Medical School, Minneapolis, 
      Minnesota 55455, USA.
FAU - Han, Jin-Young
AU  - Han JY
LA  - eng
GR  - K08 AI076520/AI/NIAID NIH HHS/United States
GR  - K08-AI076520/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100113
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Caspase Inhibitors)
RN  - 0 (Fas-Associated Death Domain Protein)
RN  - 0 (Oligopeptides)
RN  - 0 (benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone)
RN  - EC 3.4.22.- (Caspase 8)
RN  - EC 3.4.22.- (Caspase 9)
SB  - IM
MH  - Apoptosis/*physiology
MH  - Caspase 8/genetics/metabolism
MH  - Caspase 9/genetics/*metabolism
MH  - Caspase Inhibitors
MH  - Enzyme Activation
MH  - Fas-Associated Death Domain Protein/genetics/metabolism
MH  - Fibroblasts/cytology/virology
MH  - Herpesvirus 2, Human/*metabolism/pathogenicity
MH  - Humans
MH  - Jurkat Cells
MH  - Oligopeptides/metabolism
MH  - T-Lymphocytes/cytology/*enzymology/*physiology/virology
PMC - PMC2826057
EDAT- 2010/01/15 06:00
MHDA- 2010/04/03 06:00
PMCR- 2010/09/01
CRDT- 2010/01/15 06:00
PHST- 2010/01/15 06:00 [entrez]
PHST- 2010/01/15 06:00 [pubmed]
PHST- 2010/04/03 06:00 [medline]
PHST- 2010/09/01 00:00 [pmc-release]
AID - JVI.01726-09 [pii]
AID - 1726-09 [pii]
AID - 10.1128/JVI.01726-09 [doi]
PST - ppublish
SO  - J Virol. 2010 Mar;84(6):3116-20. doi: 10.1128/JVI.01726-09. Epub 2010 Jan 13.