PMID- 20072141
OWN - NLM
STAT- MEDLINE
DCOM- 20100903
LR  - 20211020
IS  - 1476-5470 (Electronic)
IS  - 1466-4879 (Print)
IS  - 1466-4879 (Linking)
VI  - 11
IP  - 4
DP  - 2010 Jun
TI  - Haplotype-dependent HLA susceptibility to nasopharyngeal carcinoma in a Southern 
      Chinese population.
PG  - 334-42
LID - 10.1038/gene.2009.109 [doi]
AB  - We have conducted a comprehensive case-control study of a nasopharyngeal 
      carcinoma (NPC) population cohort from Guangxi Province of Southern China, a 
      region with one of the highest NPC incidences on record. A total of 1407 
      individuals including NPC patients, healthy controls, and their adult children 
      were examined for the human leukocyte antigen (HLA) association, which is so far 
      the largest NPC cohort reported for such studies. Stratified analysis performed 
      in this study clearly demonstrated that while NPC protection is associated with 
      independent HLA alleles, most NPC susceptibility is strictly associated with HLA 
      haplotypes. Our study also detected for the first time that A(*)0206, a unique A2 
      subtype to South and Southeast Asia is also associated with a high risk for NPC. 
      HLA-A(*)0206, HLA-B(*)3802 alleles plus the A(*)0207-B(*)4601 and 
      A(*)3303-B(*)5801 haplotypes conferred high risk for NPC showing a combined odds 
      ratio (OR) of 2.6 (P<0.0001). HLA alleles that associate with low risk for NPC 
      include HLA-A(*)1101, B(*)27, and B(*)55 with a combined OR of 0.42 (P<0.0001). 
      The overall high frequency of NPC-susceptible HLA factors in the Guangxi 
      population is likely to have contributed to the high-NPC incidence in this 
      region.
FAU - Tang, M
AU  - Tang M
AD  - Laboratory of Genomic Diversity National Cancer Institute-Frederick, Frederick, 
      MD, USA.
FAU - Zeng, Y
AU  - Zeng Y
FAU - Poisson, A
AU  - Poisson A
FAU - Marti, D
AU  - Marti D
FAU - Guan, L
AU  - Guan L
FAU - Zheng, Y
AU  - Zheng Y
FAU - Deng, H
AU  - Deng H
FAU - Liao, J
AU  - Liao J
FAU - Guo, X
AU  - Guo X
FAU - Sun, S
AU  - Sun S
FAU - Nelson, G
AU  - Nelson G
FAU - de The, G
AU  - de The G
FAU - Winkler, C A
AU  - Winkler CA
FAU - O'Brien, S J
AU  - O'Brien SJ
FAU - Carrington, M
AU  - Carrington M
FAU - Gao, X
AU  - Gao X
LA  - eng
GR  - HHSN261200800001C/RC/CCR NIH HHS/United States
GR  - HHSN261200800001E/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100114
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Cohort Studies
MH  - HLA Antigens/*genetics
MH  - *Haplotypes
MH  - Humans
MH  - Incidence
MH  - Nasopharyngeal Neoplasms/epidemiology/ethnology/*genetics
PMC - PMC3737777
MID - NIHMS493525
COIS- Conflict of interest The authors declare no conflict of interest
EDAT- 2010/01/15 06:00
MHDA- 2010/09/04 06:00
PMCR- 2013/08/08
CRDT- 2010/01/15 06:00
PHST- 2010/01/15 06:00 [entrez]
PHST- 2010/01/15 06:00 [pubmed]
PHST- 2010/09/04 06:00 [medline]
PHST- 2013/08/08 00:00 [pmc-release]
AID - gene2009109 [pii]
AID - 10.1038/gene.2009.109 [doi]
PST - ppublish
SO  - Genes Immun. 2010 Jun;11(4):334-42. doi: 10.1038/gene.2009.109. Epub 2010 Jan 14.