PMID- 20074071
OWN - NLM
STAT- MEDLINE
DCOM- 20100315
LR  - 20101118
IS  - 1470-8752 (Electronic)
IS  - 0300-5127 (Linking)
VI  - 38
IP  - Pt 1
DP  - 2010 Feb
TI  - Exploring the relationship between interphase gene positioning, transcriptional 
      regulation and the nuclear matrix.
PG  - 263-7
LID - 10.1042/BST0380263 [doi]
AB  - Since the advent of FISH (fluorescence in situ hybridization), there have been 
      major advances in our understanding of how the genome is organized in interphase 
      nuclei. Indeed, this organization is found to be non-random and individual 
      chromosomes occupy discrete regions known as territories. Determining the factors 
      that drive the spatial positioning of these territories within nuclei has caused 
      much debate; however, in proliferating cells, there is evidently a correlation 
      between radial positioning and gene density. Indeed, gene-poor chromosomes tend 
      to be located towards the nuclear edge, while those that are more gene-rich are 
      positioned more internally. These observations pose a number of questions: first, 
      what is the function of this global organization and, secondly, is it 
      representative of that occurring at a more local scale? During the course of this 
      review, these questions will be considered, in light of the current literature 
      regarding the role of transcription factories and the nuclear matrix in 
      interphase genome organization.
FAU - Elcock, Lauren S
AU  - Elcock LS
AD  - Laboratory of Nuclear and Genomic Health, Centre for Cell and Chromosome Biology, 
      Brunel University, Uxbridge UB8 3PH, UK.
FAU - Bridger, Joanna M
AU  - Bridger JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Biochem Soc Trans
JT  - Biochemical Society transactions
JID - 7506897
SB  - IM
MH  - Animals
MH  - Biological Evolution
MH  - Disease/genetics
MH  - *Gene Expression Regulation
MH  - *Gene Order
MH  - Genome
MH  - Interphase/*physiology
MH  - Nuclear Matrix/*metabolism
MH  - *Transcription, Genetic
RF  - 50
EDAT- 2010/01/16 06:00
MHDA- 2010/03/17 06:00
CRDT- 2010/01/16 06:00
PHST- 2010/01/16 06:00 [entrez]
PHST- 2010/01/16 06:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - BST0380263 [pii]
AID - 10.1042/BST0380263 [doi]
PST - ppublish
SO  - Biochem Soc Trans. 2010 Feb;38(Pt 1):263-7. doi: 10.1042/BST0380263.