PMID- 20074602
OWN - NLM
STAT- MEDLINE
DCOM- 20100907
LR  - 20100301
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 71
IP  - 3
DP  - 2010 Mar
TI  - HLA antigen sharing between mother and fetus as a risk factor for eclampsia and 
      preeclampsia.
PG  - 263-7
LID - 10.1016/j.humimm.2010.01.006 [doi]
AB  - Immune maladaption between mother and infant has been suggested to induce 
      preeclampsia/eclampsia. When fetuses share more human leukocyte antigen (HLA) 
      types with their mother, immune differences would be limited and thereby could 
      affect this risk. Data from Danish women (1996-2002) with single live-birth 
      pregnancies complicated by severe preeclampsia/eclampsia were compared to women 
      with term pregnancies uncomplicated by hypertension. HLA A, B, and DR types were 
      resolved at the intermediate-level typing (antigen). A total of 201 cases and 195 
      control mother-infant pairs had complete HLA types. The odds ratios of 
      preeclampsia/eclampsia in mothers sharing both HLA antigens with their infants 
      were 1.19 (95% confidence interval: 0.81-1.76) for HLA A, 0.91 (0.59-1.42) for 
      HLA B, and 1.05 (0.5-1.59) for HLA DR antigens. No specific HLA antigens in 
      either mother or infant appeared important after Bonferroni correction, except 
      possibly DR01 in mothers (protective). Thus, maladaption mediated by adaptive 
      immunity between mother and infant is not the basis for the mother developing 
      preeclampsia/eclampsia.
CI  - (c) 2010 American Society for Histocompatibility and Immunogenetics. Published by 
      Elsevier Inc. All rights reserved.
FAU - Biggar, Robert J
AU  - Biggar RJ
AD  - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. 
      rjbiggar@gmail.com
FAU - Poulsen, Gry
AU  - Poulsen G
FAU - Ng, Jennifer
AU  - Ng J
FAU - Melbye, Mads
AU  - Melbye M
FAU - Boyd, Heather A
AU  - Boyd HA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100125
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Denmark
MH  - Eclampsia/epidemiology/*genetics/metabolism
MH  - Female
MH  - Fetus
MH  - Genetic Association Studies
MH  - HLA Antigens/*genetics/metabolism
MH  - Histocompatibility/genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Maternal-Fetal Exchange/*immunology
MH  - Pre-Eclampsia/epidemiology/*genetics/metabolism
MH  - Pregnancy
MH  - Prospective Studies
MH  - Registries
MH  - Risk Factors
EDAT- 2010/01/16 06:00
MHDA- 2010/09/08 06:00
CRDT- 2010/01/16 06:00
PHST- 2009/07/17 00:00 [received]
PHST- 2010/01/04 00:00 [revised]
PHST- 2010/01/07 00:00 [accepted]
PHST- 2010/01/16 06:00 [entrez]
PHST- 2010/01/16 06:00 [pubmed]
PHST- 2010/09/08 06:00 [medline]
AID - S0198-8859(10)00007-8 [pii]
AID - 10.1016/j.humimm.2010.01.006 [doi]
PST - ppublish
SO  - Hum Immunol. 2010 Mar;71(3):263-7. doi: 10.1016/j.humimm.2010.01.006. Epub 2010 
      Jan 25.