PMID- 20075245
OWN - NLM
STAT- MEDLINE
DCOM- 20100201
LR  - 20220409
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 327
IP  - 5963
DP  - 2010 Jan 15
TI  - The NLRP3 inflammasome: a sensor for metabolic danger?
PG  - 296-300
LID - 10.1126/science.1184003 [doi]
AB  - Interleukin-1beta (IL-1beta), reactive oxygen species (ROS), and 
      thioredoxin-interacting protein (TXNIP) are all implicated in the pathogenesis of 
      type 2 diabetes mellitus (T2DM). Here we review mechanisms directing IL-1beta 
      production and its pathogenic role in islet dysfunction during chronic 
      hyperglycemia. In doing so, we integrate previously disparate disease-driving 
      mechanisms for IL-1beta, ROS, and TXNIP in T2DM into one unifying model in which 
      the NLRP3 inflammasome plays a central role. The NLRP3 inflammasome also drives 
      IL-1beta maturation and secretion in another disease of metabolic dysregulation, 
      gout. Thus, we propose that the NLRP3 inflammasome contributes to the 
      pathogenesis of T2DM and gout by functioning as a sensor for metabolic stress.
FAU - Schroder, Kate
AU  - Schroder K
AD  - Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, 
      Switzerland.
FAU - Zhou, Rongbin
AU  - Zhou R
FAU - Tschopp, Jurg
AU  - Tschopp J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Carrier Proteins)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Multiprotein Complexes)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (NLRP3 protein, human)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (TXNIP protein, human)
SB  - IM
MH  - Animals
MH  - Carrier Proteins/*metabolism
MH  - Diabetes Mellitus, Type 2/immunology/*metabolism/physiopathology
MH  - Gout/immunology/metabolism
MH  - Humans
MH  - *Inflammation
MH  - Insulin-Secreting Cells/physiology
MH  - Interleukin-1beta/metabolism
MH  - Multiprotein Complexes/*metabolism
MH  - NLR Family, Pyrin Domain-Containing 3 Protein
MH  - Reactive Oxygen Species/metabolism
MH  - *Stress, Physiological
RF  - 53
EDAT- 2010/01/16 06:00
MHDA- 2010/02/02 06:00
CRDT- 2010/01/16 06:00
PHST- 2010/01/16 06:00 [entrez]
PHST- 2010/01/16 06:00 [pubmed]
PHST- 2010/02/02 06:00 [medline]
AID - 327/5963/296 [pii]
AID - 10.1126/science.1184003 [doi]
PST - ppublish
SO  - Science. 2010 Jan 15;327(5963):296-300. doi: 10.1126/science.1184003.