PMID- 20075550
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20220211
IS  - 1998-3654 (Electronic)
IS  - 0019-5359 (Linking)
VI  - 63
IP  - 11
DP  - 2009 Nov
TI  - Metformin--a convenient alternative to insulin for Indian women with diabetes in 
      pregnancy.
PG  - 491-7
AB  - OBJECTIVE: To compare the use of metformin with that of insulin for the treatment 
      of gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) 
      unresponsive to diet therapy. MATERIALS AND METHODS: In this prospective 
      observational study, maternal glycemic control and perinatal outcome in diabetic 
      pregnancies were compared between 2 obstetric units, one using insulin therapy 
      and the other using metformin therapy. Baseline pretreatment glycemic profile was 
      done and then repeated weekly throughout pregnancy. The outcome measures studied 
      were glycemic control, maternal complications and perinatal outcome. RESULTS: 
      Sixty women with gestational and type 2 diabetes were enrolled, 30 each for 
      metformin and insulin. Both groups were comparable with respect to age, body mass 
      index (BMI), parity and pretreatment plasma glucose levels. Glycemic control was 
      better with metformin after 1 week of therapy and also throughout gestation (P = 
      0.03-0.007). There were no major complications or perinatal deaths in this study. 
      Mean gestational age and birth weight (2.9 +/- 0.4 kg versus 3.1 +/- 0.4 kg, P = 
      0.30) were comparable. However, there was a significant increase in neonatal 
      intensive care unit (NICU) admission and stay for babies born in the insulin 
      group. The cost of treatment was tenfold higher in thethe insulin group. 
      CONCLUSION: Metformin is clinically effective, cheap and a safe alternative to 
      insulin therapy in pregnant diabetic women.
FAU - Rai, Lavanya
AU  - Rai L
AD  - Department of Obstetrics and Gynecology, Kasturba Medical College Hospital, 
      Manipal, Karnataka, India. railavanya@yahoo.com
FAU - Meenakshi, D
AU  - Meenakshi D
FAU - Kamath, Asha
AU  - Kamath A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - India
TA  - Indian J Med Sci
JT  - Indian journal of medical sciences
JID - 0373023
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Analysis of Variance
MH  - Blood Glucose
MH  - Body Mass Index
MH  - Confidence Intervals
MH  - Diabetes Mellitus, Type 2/drug therapy
MH  - Diabetes, Gestational/*drug therapy
MH  - Female
MH  - Glycemic Index
MH  - Humans
MH  - Hypoglycemic Agents/*therapeutic use
MH  - India
MH  - Insulin/therapeutic use
MH  - Insulin Resistance
MH  - Intensive Care Units, Neonatal
MH  - Length of Stay
MH  - Metformin/*therapeutic use
MH  - Pregnancy
MH  - Prospective Studies
EDAT- 2010/01/16 06:00
MHDA- 2011/06/03 06:00
CRDT- 2010/01/16 06:00
PHST- 2010/01/16 06:00 [entrez]
PHST- 2010/01/16 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - IndianJMedSci_2009_63_11_491_58878 [pii]
PST - ppublish
SO  - Indian J Med Sci. 2009 Nov;63(11):491-7.