PMID- 20077058
OWN - NLM
STAT- MEDLINE
DCOM- 20100405
LR  - 20221207
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 603
DP  - 2010
TI  - Quantification of antidepressants using gas chromatography-mass spectrometry.
PG  - 45-56
LID - 10.1007/978-1-60761-459-3_5 [doi]
AB  - Antidepressants are of great interest to clinical and forensic toxicologists as 
      they are frequently used in suicidal gestures; they can be the source of drug 
      interactions and some have narrow therapeutic indices making the potential for 
      toxicity more likely. There are five categories of antidepressants based on 
      function and/or structure. These are monoamine oxidase inhibitors (MAOI), cyclic 
      antidepressants including tricyclic and tetracyclic compounds (TCA), selective 
      serotonin reuptake inhibitors (SSRI), serotonin-norepinephrine reuptake 
      inhibitors (SNRI), and atypical compounds. This method is designed to detect the 
      presence of antidepressant drugs in blood/serum, urine, and tissue specimens 
      using gas chromatography/mass spectrometry (GC/MS) following liquid-liquid 
      extraction (LLE) and identified by relative retention times and mass spectra.
FAU - Winecker, Ruth E
AU  - Winecker RE
AD  - North Carolina Office of the Chief Medical Examiner and Department of Pathology 
      and Laboratory, Medicine University of North Carolina School of Medicine, Chapel 
      Hill, NC, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - 0 (Antidepressive Agents)
RN  - 0 (Antidepressive Agents, Tricyclic)
RN  - 0 (Monoamine Oxidase Inhibitors)
RN  - 0 (Serotonin Uptake Inhibitors)
SB  - IM
MH  - Antidepressive Agents/*blood/therapeutic use/*urine
MH  - Antidepressive Agents, Tricyclic/blood/therapeutic use/urine
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Humans
MH  - Monoamine Oxidase Inhibitors/blood/therapeutic use/urine
MH  - Reproducibility of Results
MH  - Selective Serotonin Reuptake Inhibitors/blood/therapeutic use/urine
EDAT- 2010/01/16 06:00
MHDA- 2010/04/07 06:00
CRDT- 2010/01/16 06:00
PHST- 2010/01/16 06:00 [entrez]
PHST- 2010/01/16 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - 10.1007/978-1-60761-459-3_5 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2010;603:45-56. doi: 10.1007/978-1-60761-459-3_5.