PMID- 20078375
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20221207
IS  - 1747-7174 (Electronic)
IS  - 1747-7166 (Print)
IS  - 1747-7166 (Linking)
VI  - 5
IP  - 4
DP  - 2010 Aug
TI  - Sex dimorphisms in inflammatory markers and adiposity in African-American youth.
PG  - 327-33
LID - 10.3109/17477160903497019 [doi]
AB  - OBJECTIVE: There are demonstrated sex differences in the association between 
      adiposity and inflammation in adults. Our aim was to determine sex differences in 
      inflammatory markers and in the association between adiposity and inflammation in 
      a sample of African-American adolescents. METHODS: Adiposity variables including 
      body mass index (BMI), waist circumference, weight, total fat, trunk fat, and 
      inflammatory markers including interleukin-6 (IL-6), leptin, monocyte chemotactic 
      protein 1 (MCP1), C-reactive Protein (CRP), adiponectin were examined in 166 (53% 
      female) African-American adolescents, aged 14-19 years. Total fat and trunk fat 
      were measured using Dual-Energy X-ray Absorptiometry (DXA). RESULTS: Results 
      revealed males had higher weight (p=0.01); females had higher BMI, trunk fat, and 
      total fat (p's <0.01). With inflammation, males had higher MCP1 (p=0.024); 
      females had higher leptin (p<0.001), adiponectin (p=0.006), and IL-6 (p=0.026). 
      Partial correlations in males indicated associations of adiposity variables with 
      leptin, adiponectin (all p's <0.01), and CRP (p<0.05); in females, leptin, CRP, 
      and IL-6 were associated with adiposity variables (all p's <0.05). multiple 
      regression analyses revealed female adiposity variables predicted CRP, 
      (R(2)=0.254), IL-6 (R(2)=0.167), and MCP1 (R(2)=0.220). Adiposity variables in 
      males predicted lower adiponectin (R(2)=0245). For both, leptin was predicted by 
      adiposity (males R(2)=0.420 and females R(2)=0.410). CONCLUSIONS: Data indicate 
      clear sex dimorphisms in the associations between inflammatory markers and 
      adiposity in African-American adolescents, suggesting that preventive measures 
      and treatments for adolescent obesity may need to be sex-specific.
FAU - Petty, Karen H
AU  - Petty KH
AD  - Department of Pediatrics, Georgia Prevention Institute, Medical College of 
      Georgia, Augusta, GA 30912, USA.
FAU - Li, Ke
AU  - Li K
FAU - Dong, Yanbin
AU  - Dong Y
FAU - Fortenberry, Jennifer
AU  - Fortenberry J
FAU - Stallmann-Jorgensen, Inger
AU  - Stallmann-Jorgensen I
FAU - Guo, Dehuang
AU  - Guo D
FAU - Zhu, Haidong
AU  - Zhu H
LA  - eng
GR  - R01 HL077230/HL/NHLBI NIH HHS/United States
GR  - R21 HL085817/HL/NHLBI NIH HHS/United States
GR  - HL077230/HL/NHLBI NIH HHS/United States
GR  - HL085817/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Int J Pediatr Obes
JT  - International journal of pediatric obesity : IJPO : an official journal of the 
      International Association for the Study of Obesity
JID - 101256330
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adiposity/*physiology
MH  - Adolescent
MH  - *Black or African American
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Female
MH  - Humans
MH  - Inflammation/*blood/epidemiology
MH  - Male
MH  - Obesity/*blood/ethnology/*physiopathology
MH  - Sex Factors
MH  - Young Adult
PMC - PMC3826793
MID - NIHMS526389
EDAT- 2010/01/19 06:00
MHDA- 2010/10/13 06:00
PMCR- 2013/11/13
CRDT- 2010/01/19 06:00
PHST- 2010/01/19 06:00 [entrez]
PHST- 2010/01/19 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
PHST- 2013/11/13 00:00 [pmc-release]
AID - 10.3109/17477160903497019 [doi]
PST - ppublish
SO  - Int J Pediatr Obes. 2010 Aug;5(4):327-33. doi: 10.3109/17477160903497019.