PMID- 20079820
OWN - NLM
STAT- MEDLINE
DCOM- 20100513
LR  - 20240312
IS  - 1878-5891 (Electronic)
IS  - 0378-5955 (Print)
IS  - 0378-5955 (Linking)
VI  - 261
IP  - 1-2
DP  - 2010 Mar
TI  - Auditory function in rhesus monkeys: effects of aging and caloric restriction in 
      the Wisconsin monkeys five years later.
PG  - 75-81
LID - 10.1016/j.heares.2010.01.006 [doi]
AB  - Caloric restriction (CR) slows aging in many species and protects some animals 
      from age-related hearing loss (ARHL), but the effect on humans is not yet known. 
      Because rhesus monkeys are long-lived primates that are phylogenically closer to 
      humans than other research animals are, they provide a better model for studying 
      the effects of CR in aging and ARHL. Subjects were from the pool of 55 rhesus 
      monkeys aged 15-28 years who had been in the Wisconsin study on CR and aging for 
      8-13.5 years. Distortion product otoacoustic emissions (DPOAE) with f2 
      frequencies from 2211 to 8837 Hz and auditory brainstem response (ABR) thresholds 
      from clicks and 8, 16, and 32 kHz tone bursts were obtained. DPOAE levels 
      declined linearly at approximately 1 dB/year, but that rate doubled for the 
      highest frequencies in the oldest monkeys. There were no interactions for diet 
      condition or sex. ABR thresholds to clicks and tone bursts showed increases with 
      aging. Borderline significance was shown for diet in the thresholds at 8 kHz 
      stimuli, with monkeys on caloric restriction having lower thresholds. Because the 
      rhesus monkeys have a maximum longevity of 40 years, the full benefits of CR may 
      not yet be realized.
CI  - 2010 Elsevier B.V. All rights reserved.
FAU - Fowler, Cynthia G
AU  - Fowler CG
AD  - Department of Communicative Disorders, University of Wisconsin-Madison, 1975 
      Willow Drive, Madison, WI 53706, USA. cgfowler@wisc.edu
FAU - Chiasson, Kirstin Beach
AU  - Chiasson KB
FAU - Leslie, Tami Hanson
AU  - Leslie TH
FAU - Thomas, Denise
AU  - Thomas D
FAU - Beasley, T Mark
AU  - Beasley TM
FAU - Kemnitz, Joseph W
AU  - Kemnitz JW
FAU - Weindruch, Richard
AU  - Weindruch R
LA  - eng
GR  - P51 RR000167/RR/NCRR NIH HHS/United States
GR  - P51 RR000167-48/RR/NCRR NIH HHS/United States
GR  - RR000167/RR/NCRR NIH HHS/United States
GR  - P51 RR000167-485047/RR/NCRR NIH HHS/United States
GR  - P01 AG11915/AG/NIA NIH HHS/United States
GR  - P01 AG011915-14/AG/NIA NIH HHS/United States
GR  - P01 AG011915/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100115
PL  - Netherlands
TA  - Hear Res
JT  - Hearing research
JID - 7900445
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Auditory Pathways/*physiology
MH  - Auditory Threshold/physiology
MH  - *Caloric Restriction
MH  - Evoked Potentials, Auditory, Brain Stem/physiology
MH  - Female
MH  - Hearing Disorders/physiopathology
MH  - Hearing Loss/physiopathology
MH  - Macaca mulatta/*physiology
MH  - Male
MH  - Models, Animal
MH  - Time Factors
PMC - PMC2855903
MID - NIHMS178171
EDAT- 2010/01/19 06:00
MHDA- 2010/05/14 06:00
PMCR- 2011/03/01
CRDT- 2010/01/19 06:00
PHST- 2009/06/28 00:00 [received]
PHST- 2009/12/21 00:00 [revised]
PHST- 2010/01/11 00:00 [accepted]
PHST- 2010/01/19 06:00 [entrez]
PHST- 2010/01/19 06:00 [pubmed]
PHST- 2010/05/14 06:00 [medline]
PHST- 2011/03/01 00:00 [pmc-release]
AID - S0378-5955(10)00019-5 [pii]
AID - 10.1016/j.heares.2010.01.006 [doi]
PST - ppublish
SO  - Hear Res. 2010 Mar;261(1-2):75-81. doi: 10.1016/j.heares.2010.01.006. Epub 2010 
      Jan 15.