PMID- 20080471
OWN - NLM
STAT- MEDLINE
DCOM- 20100402
LR  - 20211020
IS  - 1699-3055 (Electronic)
IS  - 1699-048X (Linking)
VI  - 12
IP  - 1
DP  - 2010 Jan
TI  - Neuroblastoma in adolescents: genetic and clinical characterisation.
PG  - 49-54
LID - 10.1007/s12094-010-0466-z [doi]
AB  - BACKGROUND: Age at diagnosis is an important risk factor in neuroblastoma (NB) 
      with worse prognosis in children older than 18 months. A more indolent course 
      with long-term relapses and fatal outcome has been described in small series of 
      adolescents. Our objective was to describe biological factors that contribute to 
      this particular behaviour and could be helpful in their treatment. PROCEDURE: NB 
      cases older than 10 years of age at diagnosis registered in the files of the 
      Neuroblastoma Group of SEOP from 1992 to 2007 were included. Disease extension 
      was classified according to the International Neuroblastoma Staging System 
      (INSS). Tumour samples were studied according to the International Neuroblastoma 
      Pathology Classification (INPC). Biological studies included MNA, 1p, 11q and 17q 
      status and ploidy. RESULTS: Twenty-two patients, from 10.1 to 24.6 years old, 
      were included. Advanced stages predominated. 14/17 patients presented 
      unfavourable histology. None had NMA or 1p del. However, 11q del was found in 
      8/13 cases and 17q gain in 7/11. Overall survival (OS) and event-free survival 
      (EFS) for the entire series at 5 years were 0.45 and 0.32, respectively. 
      Moreover, 5-year OS and EFS for stage 4 patients were 0.33 and 0.15. CONCLUSIONS: 
      NB in adolescents is a special subgroup characterised by high-risk prognostic 
      features which differ from those seen in younger patients, especially in relation 
      to genetic abnormalities. The outcome in stage 4 was worse than in younger 
      metastatic children, outlining the need for new therapeutic approaches in this 
      subgroup of patients. The exact cut-off to separate older patients has not yet 
      been established and will probably be based on biology.
FAU - Castel, Victoria
AU  - Castel V
AD  - Unidad de Oncologia Pediatrica, Hospital Universitario La Fe, Valencia, Spain. 
      castel_vic@gva.es
FAU - Villamon, Eva
AU  - Villamon E
FAU - Canete, Adela
AU  - Canete A
FAU - Navarro, Samuel
AU  - Navarro S
FAU - Ruiz, Amparo
AU  - Ruiz A
FAU - Melero, Carmen
AU  - Melero C
FAU - Herrero, Antonio
AU  - Herrero A
FAU - Yanez, Yania
AU  - Yanez Y
FAU - Noguera, Rosa
AU  - Noguera R
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Clin Transl Oncol
JT  - Clinical & translational oncology : official publication of the Federation of 
      Spanish Oncology Societies and of the National Cancer Institute of Mexico
JID - 101247119
RN  - 0 (MYCN protein, human)
RN  - 0 (N-Myc Proto-Oncogene Protein)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Oncogene Proteins)
SB  - IM
MH  - Abdominal Neoplasms/*diagnosis/epidemiology/genetics/pathology
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Child
MH  - Chromosome Aberrations/statistics & numerical data
MH  - Chromosomes, Human, Pair 1
MH  - Chromosomes, Human, Pair 11
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - N-Myc Proto-Oncogene Protein
MH  - Neoplasm Metastasis
MH  - Neuroblastoma/*diagnosis/epidemiology/genetics/pathology
MH  - Nuclear Proteins/genetics
MH  - Oncogene Proteins/genetics
MH  - Prognosis
MH  - Recurrence
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2010/01/19 06:00
MHDA- 2010/04/03 06:00
CRDT- 2010/01/19 06:00
PHST- 2010/01/19 06:00 [entrez]
PHST- 2010/01/19 06:00 [pubmed]
PHST- 2010/04/03 06:00 [medline]
AID - CLAT301 [pii]
AID - 10.1007/s12094-010-0466-z [doi]
PST - ppublish
SO  - Clin Transl Oncol. 2010 Jan;12(1):49-54. doi: 10.1007/s12094-010-0466-z.