PMID- 20081262
OWN - NLM
STAT- MEDLINE
DCOM- 20100219
LR  - 20151119
VI  - 13
IP  - 3
DP  - 2009 Jul-Sep
TI  - [Gene polymorphism of transforming growth factor beta1 (TGF-beta1) in the 
      pathogenesis and clinical course of chronic hepatitis in children].
PG  - 171-9
AB  - Transforming growth factor beta1 (TGF-beta1) is a cytokine modulating the immune 
      response. The role of TGF-beta1 gene polymorphisms in the incidence and 
      modification of the clinical course of these diseases has been recently 
      evaluated. THE AIM of the study was to assess the relation between TGF-beta1gene 
      polymorphism and the incidence of chronic hepatitis, the course of the disease, 
      TGF-beta1 level in plasma and TGF-beta1 mRNA expression in liver tissue. PATIENTS 
      AND METHODS: The studied group comprised 21 patients with chronic hepatitis 
      including 10 with HBV infection, 4 with HCV infection and 7 with autoimmune 
      hepatitis (AIH). Forty-two children were included in the control group. Analysis 
      of four studied polymorphisms of TGF-beta1 gene was based on CAPS (Cleaved 
      Amplified Polymorphic Sequence) method, TGF-beta1 level in plasma was estimated 
      using sandwich ELISA. TGF-beta1 mRNA expression was evaluated by reverse 
      transcription and real-time polymerase chain reaction (Real-Time PCR). RESULTS: 
      No correlation between studied polymorphisms and the incidence or clinical course 
      of chronic hepatitis was found. There were no significant differences in 
      TGF-beta1 level in plasma and mRNA expression depending on polymorphisms of 
      TGF-beta1 gene. CONCLUSIONS: 1. The polymorphisms of TGF-beta1 gene do not appear 
      to influence the incidence and clinical course of chronic hepatitis in children. 
      2. Due to relatively low number of patients in the analysed groups it seems 
      advisable to perform similar complex studies in larger groups of children with 
      chronic hepatitis.
FAU - Liberek, Anna
AU  - Liberek A
AD  - Katedra i Klinika Pediatrii, Gastroenterologii, Hepatologii i Zywienia Dzieci 
      Gdanskiego Uniwersytetu Medycznego, ul. Nowe Ogrody 1/6, 80-803 Gdansk. 
      alib@amg.gda.pl
FAU - Jakobkiewicz-Banecka, Joanna
AU  - Jakobkiewicz-Banecka J
FAU - Kloska, Anna
AU  - Kloska A
FAU - Swiderska, Joanna
AU  - Swiderska J
FAU - Marek, Andrzej
AU  - Marek A
FAU - Luczak, Grazyna
AU  - Luczak G
FAU - Wierzbicki, Piotr M
AU  - Wierzbicki PM
FAU - Kmiec, Zbigniew
AU  - Kmiec Z
FAU - Szlagatys-Sidorkiewicz, Agnieszka
AU  - Szlagatys-Sidorkiewicz A
FAU - Marek, Krzysztof
AU  - Marek K
FAU - Sznurkowska, Katarzyna
AU  - Sznurkowska K
FAU - Gora-Gebka, Magdalena
AU  - Gora-Gebka M
FAU - Liberek, Tomasz
AU  - Liberek T
FAU - Zagierski, Maciej
AU  - Zagierski M
FAU - Kaminska, Barbara
AU  - Kaminska B
FAU - Wegrzyn, Grzegorz
AU  - Wegrzyn G
LA  - pol
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Polimorfizm genu transformujacego czynnika wzrostu beta1 (TGF-beta1) w 
      etiopatogenezie i przebiegu klinicznym przewleklych zapalen watroby u dzieci.
PL  - Poland
TA  - Med Wieku Rozwoj
JT  - Medycyna wieku rozwojowego
JID - 100928610
RN  - 0 (Biomarkers)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Adolescent
MH  - Biomarkers/blood
MH  - Biopsy
MH  - Child
MH  - Disease Progression
MH  - Female
MH  - Hepatitis B, Chronic/blood/*genetics/pathology
MH  - Hepatitis C, Chronic/blood/*genetics/pathology
MH  - Hepatitis, Autoimmune/blood/*genetics/pathology
MH  - Humans
MH  - Liver/pathology
MH  - Male
MH  - *Polymorphism, Genetic
MH  - RNA, Messenger/analysis
MH  - Reference Values
MH  - Transforming Growth Factor beta1/blood/*genetics
EDAT- 2010/01/19 06:00
MHDA- 2010/02/20 06:00
CRDT- 2010/01/19 06:00
PHST- 2010/01/19 06:00 [entrez]
PHST- 2010/01/19 06:00 [pubmed]
PHST- 2010/02/20 06:00 [medline]
PST - ppublish
SO  - Med Wieku Rozwoj. 2009 Jul-Sep;13(3):171-9.