PMID- 20081877
OWN - NLM
STAT- MEDLINE
DCOM- 20100308
LR  - 20220409
IS  - 2042-0226 (Electronic)
IS  - 1672-7681 (Print)
IS  - 1672-7681 (Linking)
VI  - 7
IP  - 1
DP  - 2010 Jan
TI  - Modulation of morphological changes of microglia and neuroprotection by monocyte 
      chemoattractant protein-1 in experimental glaucoma.
PG  - 61-8
LID - 10.1038/cmi.2009.110 [doi]
AB  - Monocyte chemoattractant protein-1 (MCP-1)/CCL2 is a C-C chemokine involved in 
      the activation and recruitment of monocytic cells to injury sites. MCP-1/CCL2 can 
      induce either neuroprotection or neurodestruction in vitro, depending on the 
      experimental model. We aim to use MCP-1/CCL2 as an experimental tool to 
      investigate the morphological changes of microglia when loss of healthy retinal 
      ganglion cells (RGCs) is exacerbated or attenuated in an experimental glaucoma 
      model. While a high concentration (1000 ng) of MCP-1/CCL2 and lipopolysaccharide 
      (LPS)-exacerbated RGC loss, 100 ng MCP-1/CCL2 provided neuroprotection towards 
      RGC. Neuroprotective MCP-1/CCL2 (100 ng) also upregulated insulin-like growth 
      factor-1 (IGF-1) immunoreactivity in the RGCs. The neuroprotective effect of 
      MCP-1/CCL2 was not due to the massive infiltration of microglia/macrophages. 
      Taken together, this is the first report showing that an appropriate amount of 
      MCP-1/CCL2 can protect RGCs in experimental glaucoma.
FAU - Chiu, Kin
AU  - Chiu K
AD  - Laboratory of Neurodegenerative Diseases, Department of Anatomy, University of 
      Hong Kong, Pokfulam, Hong Kong, China.
FAU - Yeung, Sze-Chun
AU  - Yeung SC
FAU - So, Kwok-Fai
AU  - So KF
FAU - Chang, Raymond Chuen-Chung
AU  - Chang RC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Cell Mol Immunol
JT  - Cellular & molecular immunology
JID - 101242872
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - *Cell Shape
MH  - Chemokine CCL2/*immunology
MH  - Disease Models, Animal
MH  - Female
MH  - Glaucoma/*immunology/*pathology
MH  - Insulin-Like Growth Factor I/immunology
MH  - Microglia/*immunology/*pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
PMC - PMC4003260
EDAT- 2010/01/19 06:00
MHDA- 2010/03/10 06:00
PMCR- 2010/01/01
CRDT- 2010/01/19 06:00
PHST- 2010/01/19 06:00 [entrez]
PHST- 2010/01/19 06:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
PHST- 2010/01/01 00:00 [pmc-release]
AID - cmi2009110 [pii]
AID - 10.1038/cmi.2009.110 [doi]
PST - ppublish
SO  - Cell Mol Immunol. 2010 Jan;7(1):61-8. doi: 10.1038/cmi.2009.110.