PMID- 20082482
OWN - NLM
STAT- MEDLINE
DCOM- 20100420
LR  - 20211020
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 16
IP  - 3
DP  - 2010 Jan 21
TI  - Immunogenetic characteristics of patients with autoimmune gastritis.
PG  - 354-8
AB  - AIM: To explore whether predisposition to autoimmune gastritis (AIG) is found in 
      human leukocyte antigen (HLA), cytokine or killer cell immunoglobulin-like 
      receptor (KIR) gene variations. METHODS: Twelve Finnish patients with 
      autoimmune-type severe atrophy of the gastric corpus were included. The patients' 
      serum was analyzed for pepsinogen I and Helicobacter pylori (H. pylori) 
      antibodies. DNA was separated and the patients were genotyped for HLA-A, B, Cw, 
      DRB1 and DQB1 antigens, and studied for single nucleotide polymorphisms for the 
      following cytokines: interleukin (IL)-1 gene cluster, IL-2, IL-4, IL-6, IL-10, 
      IL-12, interferon gamma, transforming growth factor beta, and tumor necrosis 
      factor alpha. Variation in KIR genes was also explored. The results were compared 
      with prevalence of the polymorphisms in Finnish or European populations. RESULTS: 
      All patients had pepsinogen I levels below normal (mean: 11 microg/L, range: < 5 
      to 25 microg/L). Three patients had elevated H. pylori IgG antibodies, while H. 
      pylori serology was negative in the rest of the patients. AIG patients carried 
      significantly more often HLA-DRB1*04 (58%) and DQB1*03 (83%) than the general 
      Finnish population did (28% and 51%, respectively; P = 0.045 and 0.034 by the 
      Fisher's exact test). No patient was positive for HLA-B8-DRB1*03, a 
      well-established autoimmune marker. Neither cytokine polymorphisms nor KIR gene 
      variation showed association with AIG. CONCLUSION: As explored with modern 
      DNA-based methods, HLA-DRB1*04 and DQB1*03 alleles, but not HLA-B8-DRB1*03, may 
      predispose to AIG.
FAU - Oksanen, Aino Mirjam
AU  - Oksanen AM
AD  - Herttoniemi Hospital, Health Centre, City of Helsinki, PO Box 6300, 00099 
      Helsinki, Finland. aino.oksanen@hel.fi
FAU - Haimila, Katri Eerika
AU  - Haimila KE
FAU - Rautelin, Hilpi Iris Kaarina
AU  - Rautelin HI
FAU - Partanen, Jukka Antero
AU  - Partanen JA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Cytokines)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*04 antigen)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Potassium Channels, Inwardly Rectifying)
SB  - IM
MH  - Adult
MH  - Autoimmune Diseases/ethnology/*genetics
MH  - Case-Control Studies
MH  - Cytokines/genetics
MH  - Czech Republic
MH  - Female
MH  - Finland
MH  - Gastritis/ethnology/*genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Italy
MH  - Male
MH  - Membrane Glycoproteins/*genetics
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Potassium Channels, Inwardly Rectifying/genetics
PMC - PMC2807957
EDAT- 2010/01/19 06:00
MHDA- 2010/04/21 06:00
PMCR- 2010/01/21
CRDT- 2010/01/19 06:00
PHST- 2010/01/19 06:00 [entrez]
PHST- 2010/01/19 06:00 [pubmed]
PHST- 2010/04/21 06:00 [medline]
PHST- 2010/01/21 00:00 [pmc-release]
AID - 10.3748/wjg.v16.i3.354 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2010 Jan 21;16(3):354-8. doi: 10.3748/wjg.v16.i3.354.