PMID- 20082871
OWN - NLM
STAT- MEDLINE
DCOM- 20100323
LR  - 20220316
IS  - 1873-5487 (Electronic)
IS  - 0188-4409 (Linking)
VI  - 40
IP  - 7
DP  - 2009 Oct
TI  - High prevalence of coronary heart disease in type 2 diabetic patients with 
      non-alcoholic fatty liver disease.
PG  - 571-5
LID - 10.1016/j.arcmed.2009.07.009 [doi]
AB  - BACKGROUND AND AIMS: Nonalcoholic fatty liver disease (NAFLD) is closely 
      associated with insulin resistance and metabolic syndrome. Prevalence of NAFLD 
      increases greatly in patients with type 2 diabetes mellitus (T2DM), and it may 
      also increase cardiovascular disease mortality and morbidity. The aim of our 
      study was to investigate the prevalence of NAFLD in T2DM population and to 
      compare the prevalence of coronary heart disease (CHD) and its risk factors 
      between diabetic patients with and without NAFLD in a Chinese population. 
      METHODS: A cross-sectional survey was conducted among 560 cases of in-patient 
      T2DM patients from January 2002 to January 2009 in southern China. Patients were 
      divided into two groups (NAFLD and non-NAFLD) and underwent clinical examination, 
      anthropometry, laboratory tests and routine liver ultrasonography. RESULTS: 
      Prevalence of NAFLD was 75.18% (421 cases) among all participants, and 285 cases 
      (67.70%) had normal liver function and no symptoms. NAFLD group had higher body 
      mass index (BMI), waist/hip circumference ratio (WHR), alanine aminotransferase 
      (ALT), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) levels 
      than those without NAFLD (p<0.01). Moreover, the prevalence of CHD was also 
      higher in the NAFLD group (p<0.01), especially in those male patients with 
      elevated plasma ALT. CONCLUSIONS: NAFLD is a common condition among T2DM 
      patients. Its occurrence may be related to sex, age, abdominal obesity, 
      dyslipidemia metabolism, etc. and it is associated with a higher prevalence of 
      CHD. Plasma ALT levels may act as a marker.
CI  - 2009 IMSS. Published by Elsevier Inc.
FAU - Lu, Hongyun
AU  - Lu H
AD  - Department of Endocrinology, the Third Affiliated Hospital of Sun Yat-sen 
      University, Guangdong, Guangzhou, China. luhongyun1120@yahoo.com.cn
FAU - Zeng, Longyi
AU  - Zeng L
FAU - Liang, Biao
AU  - Liang B
FAU - Shu, Xiaochun
AU  - Shu X
FAU - Xie, Danhong
AU  - Xie D
LA  - eng
PT  - Journal Article
DEP - 20090925
PL  - United States
TA  - Arch Med Res
JT  - Archives of medical research
JID - 9312706
SB  - IM
MH  - Anthropometry
MH  - Body Mass Index
MH  - China/epidemiology
MH  - *Coronary Disease/epidemiology/etiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications/physiopathology
MH  - *Fatty Liver/complications/epidemiology/etiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
EDAT- 2010/01/20 06:00
MHDA- 2010/03/24 06:00
CRDT- 2010/01/20 06:00
PHST- 2009/05/20 00:00 [received]
PHST- 2009/07/02 00:00 [accepted]
PHST- 2010/01/20 06:00 [entrez]
PHST- 2010/01/20 06:00 [pubmed]
PHST- 2010/03/24 06:00 [medline]
AID - S0188-4409(09)00135-0 [pii]
AID - 10.1016/j.arcmed.2009.07.009 [doi]
PST - ppublish
SO  - Arch Med Res. 2009 Oct;40(7):571-5. doi: 10.1016/j.arcmed.2009.07.009. Epub 2009 
      Sep 25.