PMID- 20082876
OWN - NLM
STAT- MEDLINE
DCOM- 20100323
LR  - 20100119
IS  - 1873-5487 (Electronic)
IS  - 0188-4409 (Linking)
VI  - 40
IP  - 7
DP  - 2009 Oct
TI  - Influence of genetic polymorphism in matrix metalloproteinase-3 on extent of 
      coronary atherosclerosis and risk of coronary artery stenosis.
PG  - 600-4
LID - 10.1016/j.arcmed.2009.08.008 [doi]
AB  - BACKGROUND AND AIMS: Matrix metalloproteinase-3 (MMP3) is key member of the MMP 
      family. It is known to be present in coronary atherosclerosis. Several studies 
      have demonstrated that MMP-3 5A/6A polymorphism modifies each transcriptional 
      activity in an allele-specific manner. We hypothesized that this polymorphism may 
      be a risk factor for the development of coronary artery stenosis (CAS). We 
      estimated the effect of MMP3 (5A/6A) gene polymorphism on CAS risk in an Iranian 
      population. METHODS: One hundred ninety patients with CAS and 200 healthy 
      controls were in this study. MMP3 genotypes were determined by polymerase chain 
      reaction (PCR) and restriction fragment length polymorphism (RFLP). RESULTS: 
      Significant differences between cases and controls were observed for MMP3 
      genotype frequencies (chi(2)=199.305, p<0.001). The 6A allele was less frequently 
      seen in the control group compared with the disease group (85.79 vs. 78%, 
      6A/6A+5A/6A vs. 5A/5A, p< or =0.05). Association of this polymorphism with CAS 
      severity was evaluated in the two groups, and distribution of the MMP3 genotype 
      was not significantly different as compared with CAS severity (p>0.05). 
      CONCLUSIONS: These data imply involvement of the -1612 5A/6A polymorphism in CAS 
      and also that the 6A/6A MMP-3 genotype is a genetic susceptibility factor for CAS 
      (but does not affect disease severity).
CI  - 2009 IMSS. Published by Elsevier Inc.
FAU - Seifi, Morteza
AU  - Seifi M
AD  - Biochemistry Department, Iran University of Medical Sciences, Tehran, Iran. 
      morteza.seifi@iums.ac.ir
FAU - Fallah, Soudabeh
AU  - Fallah S
FAU - Firoozrai, Mohsen
AU  - Firoozrai M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arch Med Res
JT  - Archives of medical research
JID - 9312706
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Coronary Artery Disease/*genetics/pathology
MH  - Coronary Stenosis/*genetics/pathology
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Iran
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Risk Factors
EDAT- 2010/01/20 06:00
MHDA- 2010/03/24 06:00
CRDT- 2010/01/20 06:00
PHST- 2009/05/26 00:00 [received]
PHST- 2009/08/07 00:00 [accepted]
PHST- 2010/01/20 06:00 [entrez]
PHST- 2010/01/20 06:00 [pubmed]
PHST- 2010/03/24 06:00 [medline]
AID - S0188-4409(09)00150-7 [pii]
AID - 10.1016/j.arcmed.2009.08.008 [doi]
PST - ppublish
SO  - Arch Med Res. 2009 Oct;40(7):600-4. doi: 10.1016/j.arcmed.2009.08.008.