PMID- 20084368
OWN - NLM
STAT- MEDLINE
DCOM- 20100421
LR  - 20211020
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 209
IP  - 1
DP  - 2010 Mar
TI  - Dose-related effects of MDMA on psychomotor function and mood before, during, and 
      after a night of sleep loss.
PG  - 69-76
LID - 10.1007/s00213-009-1767-1 [doi]
AB  - INTRODUCTION: 3,4-methylenedioxymethamphetamine (MDMA) is known to improve 
      psychomotor function and mood when measured during daytime. However, MDMA users 
      tend to take this drug at dance parties while staying awake for prolonged periods 
      of time. SUBJECTS AND METHODS: This study was designed to assess dose-related 
      residual effects of MDMA on psychomotor function and mood after a night without 
      sleep. Sixteen recreational MDMA users received single doses of 25, 50, and 100 
      mg MDMA in a randomized, double-blind, placebo-controlled cross-over study. 
      RESULTS: Results showed that sleep loss significantly impaired psychomotor 
      function. MDMA generally did not affect performance but did improve rapid 
      information processing at the highest dose in the morning after administration. 
      In the evening, MDMA also increased subjective ratings of positive mood at every 
      dose and subjective arousal at the highest dose. These subjective effects were no 
      longer present after a night of sleep loss. DISCUSSION: It is concluded that 
      sleep deprivation impairs psychomotor function and that stimulant effects of MDMA 
      are not sufficient to compensate for this impairment.
FAU - Bosker, Wendy M
AU  - Bosker WM
AD  - Department of Neuropsychology and Psychopharmacology, Maastricht University, 
      Maastricht, The Netherlands. Wendy.bosker@maastrichtuniversity.nl
FAU - Kuypers, Kim P C
AU  - Kuypers KP
FAU - Conen, Silke
AU  - Conen S
FAU - Ramaekers, Johannes G
AU  - Ramaekers JG
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Affect/drug effects
MH  - Cross-Over Studies
MH  - Dose-Response Relationship, Drug
MH  - Double-Blind Method
MH  - Female
MH  - Hallucinogens/administration & dosage/*toxicity
MH  - Humans
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*toxicity
MH  - Psychomotor Performance/*drug effects
MH  - Sleep Deprivation
MH  - Time Factors
MH  - Young Adult
PMC - PMC2819659
EDAT- 2010/01/20 06:00
MHDA- 2010/04/22 06:00
PMCR- 2010/01/19
CRDT- 2010/01/20 06:00
PHST- 2009/08/04 00:00 [received]
PHST- 2009/12/21 00:00 [accepted]
PHST- 2010/01/20 06:00 [entrez]
PHST- 2010/01/20 06:00 [pubmed]
PHST- 2010/04/22 06:00 [medline]
PHST- 2010/01/19 00:00 [pmc-release]
AID - 1767 [pii]
AID - 10.1007/s00213-009-1767-1 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2010 Mar;209(1):69-76. doi: 10.1007/s00213-009-1767-1.