PMID- 20085778
OWN - NLM
STAT- MEDLINE
DCOM- 20100622
LR  - 20200704
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 687
IP  - 1-2
DP  - 2010 May 1
TI  - Non-targeted effects and the dose response for heavy ion tumor induction.
PG  - 49-53
LID - S0027-5107(10)00034-5 [pii]
LID - 10.1016/j.mrfmmm.2010.01.012 [doi]
AB  - Non-targeted effects (NTE), including bystander effects in neighbor cells of 
      cells directly hit by radiation tracks and genomic instability in the progeny of 
      irradiated cells, challenge traditional radiation protection paradigms on Earth. 
      It is thus of interest to understand how NTE could impact our understanding of 
      cancer risks from galactic cosmic rays (GCR), which are comprised of high-energy 
      protons and heavy ions. The most comprehensive data set for tumor induction by 
      heavy ions is the induction of Harderian gland tumors in mice by high-energy 
      protons, helium, neon, iron and niobium ions after doses of 0.05 to several Gy. 
      We report on an analysis of these data that compares a dose response model 
      motivated by the conventional targeted effects (TE) model to one which includes a 
      dose response term descriptive of non-targeted effects (NTE) in cell culture. 
      Results show that a NTE model provides an improved fit to the Harderian gland 
      data over the TE model. Relative biological effectiveness (RBE) factors are shown 
      to have much larger values at low doses based on a NTE model than the maximum RBE 
      estimates based on estimates of the ratio of initial linear slopes of heavy ions 
      compared to gamma-rays in the TE model. Our analysis provides important in vivo 
      support for the deviation from linear dose responses at low doses for high LET 
      radiation, which are best explained by a NTE model.
CI  - Published by Elsevier B.V.
FAU - Cucinotta, Francis A
AU  - Cucinotta FA
AD  - NASA, Lyndon B. Johnson Space Center, Space Radiation Program, 2101 NASA Parkway, 
      Mail Code SK, Houston, TX 77058, USA. Electronic address: 
      Francis.A.Cucinotta@nasa.gov.
FAU - Chappell, Lori J
AU  - Chappell LJ
AD  - USRA Division of Life Sciences, Houston, TX 77058, USA.
LA  - eng
PT  - Journal Article
DEP - 20100118
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Radiation
MH  - *Heavy Ions
MH  - Linear Energy Transfer
MH  - Mice
MH  - Models, Biological
MH  - *Neoplasms, Radiation-Induced
EDAT- 2010/01/21 06:00
MHDA- 2010/06/23 06:00
CRDT- 2010/01/21 06:00
PHST- 2010/01/21 06:00 [entrez]
PHST- 2010/01/21 06:00 [pubmed]
PHST- 2010/06/23 06:00 [medline]
AID - S0027-5107(10)00034-5 [pii]
AID - 10.1016/j.mrfmmm.2010.01.012 [doi]
PST - ppublish
SO  - Mutat Res. 2010 May 1;687(1-2):49-53. doi: 10.1016/j.mrfmmm.2010.01.012. Epub 
      2010 Jan 18.