PMID- 20087679
OWN - NLM
STAT- MEDLINE
DCOM- 20101021
LR  - 20211020
IS  - 1559-0755 (Electronic)
IS  - 0257-277X (Linking)
VI  - 47
IP  - 1-3
DP  - 2010 Jul
TI  - Incompatible kidney transplantation: lessons from a decade of desensitization and 
      paired kidney exchange.
PG  - 257-64
LID - 10.1007/s12026-009-8157-y [doi]
AB  - Human leukocyte antigen (HLA) sensitization and ABO incompatibility continue to 
      pose significant barriers to further expansion of live donor renal 
      transplantation. However, the recent development of effective desensitization 
      protocols and creative paired donation strategies demonstrates that the presence 
      of circulating donor HLA-specific antibodies and the use of ABO incompatible 
      organs should no longer be considered contraindications for renal 
      transplantation. It is estimated that as many as 6,000 patients on the kidney 
      transplant waiting list have incompatible living donors and could benefit from 
      these treatments. Furthermore, as our understanding of these treatment modalities 
      has improved, it is now possible to predict whether desensitization, kidney 
      paired donation or a combination of both will provide an individual patient with 
      their best chance for successful renal transplantation.
FAU - Warren, Daniel S
AU  - Warren DS
AD  - Department of Surgery, Johns Hopkins University, Ross Building Room 765, 
      Baltimore, MD 21205, USA.
FAU - Montgomery, Robert A
AU  - Montgomery RA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Immunol Res
JT  - Immunologic research
JID - 8611087
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Blood Group Incompatibility/*immunology
MH  - Desensitization, Immunologic/*methods
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - Kidney/immunology
MH  - Kidney Transplantation/*immunology
MH  - Living Donors
MH  - Tissue and Organ Procurement/*methods
MH  - Waiting Lists
EDAT- 2010/01/21 06:00
MHDA- 2010/10/22 06:00
CRDT- 2010/01/21 06:00
PHST- 2010/01/21 06:00 [entrez]
PHST- 2010/01/21 06:00 [pubmed]
PHST- 2010/10/22 06:00 [medline]
AID - 10.1007/s12026-009-8157-y [doi]
PST - ppublish
SO  - Immunol Res. 2010 Jul;47(1-3):257-64. doi: 10.1007/s12026-009-8157-y.