PMID- 20087796
OWN - NLM
STAT- MEDLINE
DCOM- 20100607
LR  - 20211020
IS  - 1865-3774 (Electronic)
IS  - 0925-5710 (Linking)
VI  - 91
IP  - 2
DP  - 2010 Mar
TI  - Adult bone marrow cells can differentiate into hemopoietic cells and endothelial 
      cells but not into other lineage cells in normal growth and normal life.
PG  - 213-8
LID - 10.1007/s12185-009-0479-y [doi]
AB  - There have been reports that bone marrow cells (BMCs) can differentiate into 
      various cells and tissues and that BMCs improve the function of the injured 
      organs or reduce the organ damage, thereby rescuing the individuals from death. 
      However, these reports also noted that injuries were induced in the organs. 
      Therefore, it is not clear whether BMCs can differentiate into parenchymal cells 
      in organs in normal life or whether BMCs can supply organ-specific stem cells. In 
      this paper, we examine whether adult BMCs could contribute to the development of 
      various organs in normal development after birth and in normal life. BMCs from 
      adult eGFP mice (8 weeks old) were injected into the liver of newborn C57BL/6 
      mice. The existence of donor-derived cells in various organs was examined 1 year 
      after the injection. In the organs of recipient mice, some of the CD45(+) 
      hemopoietic cells (1.4-13.2%) and CD31(+) endothelial cells (0-2.2%) expressed 
      eGFP, though no other lineage cells did so. These results suggest that adult BMCs 
      can differentiate into not only hemopoietic cells but also vascular endothelial 
      cells, but cannot differentiate into other lineage cells in normal growth and 
      normal life.
FAU - Yanai, Seiji
AU  - Yanai S
AD  - First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, 
      Moriguchi City, Osaka 570-8506, Japan.
FAU - Adachi, Yasushi
AU  - Adachi Y
FAU - Shi, Ming
AU  - Shi M
FAU - Shigematsu, Akio
AU  - Shigematsu A
FAU - Shima, Chieko
AU  - Shima C
FAU - Imai, Yuichiro
AU  - Imai Y
FAU - Kwon, A-Hon
AU  - Kwon AH
FAU - Ikehara, Susumu
AU  - Ikehara S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100120
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - 147336-22-9 (Green Fluorescent Proteins)
RN  - EC 3.1.3.48 (Leukocyte Common Antigens)
RN  - EC 3.1.3.48 (Ptprc protein, mouse)
SB  - IM
MH  - Adult Stem Cells/*cytology/metabolism
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Bone Marrow Cells/*cytology
MH  - *Bone Marrow Transplantation
MH  - Cell Differentiation/physiology
MH  - Cell Lineage/physiology
MH  - Endothelial Cells/*cytology
MH  - Green Fluorescent Proteins/genetics
MH  - Hematopoietic Stem Cells/*cytology/metabolism
MH  - Leukocyte Common Antigens/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Transplantation Chimera
EDAT- 2010/01/21 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/01/21 06:00
PHST- 2009/01/24 00:00 [received]
PHST- 2009/12/10 00:00 [accepted]
PHST- 2009/12/05 00:00 [revised]
PHST- 2010/01/21 06:00 [entrez]
PHST- 2010/01/21 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
AID - 10.1007/s12185-009-0479-y [doi]
PST - ppublish
SO  - Int J Hematol. 2010 Mar;91(2):213-8. doi: 10.1007/s12185-009-0479-y. Epub 2010 
      Jan 20.