PMID- 20088693
OWN - NLM
STAT- MEDLINE
DCOM- 20100308
LR  - 20211020
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 201
IP  - 4
DP  - 2010 Feb 15
TI  - Transplacental congenital human herpesvirus 6 infection caused by maternal 
      chromosomally integrated virus.
PG  - 505-7
LID - 10.1086/650495 [doi]
AB  - Congenital human herpesvirus 6 (HHV-6) infection results from germline passage of 
      chromosomally integrated HHV-6 (CI-HHV-6) and from transplacental passage of 
      maternal HHV-6 infection. We aimed to determine whether CI-HHV-6 could replicate 
      and cause transplacentally acquired HHV-6 infection. HHV-6 DNA, variant type, and 
      viral loads were determined with samples (cord blood, peripheral blood, saliva, 
      urine, and hair) obtained from 6 infants with transplacentally acquired HHV-6 and 
      with samples of their parents' hair. No fathers but all mothers of infants with 
      transplacentally acquired HHV-6 had CI-HHV-6, and the mother's CI-HHV-6 variant 
      was the same variant causing the transplacentally acquired congenital HHV-6 
      infection. This suggests the possibility that CI-HHV-6 replicates and may cause 
      most, if not all, congenital HHV-6 infections.
FAU - Hall, Caroline Breese
AU  - Hall CB
AD  - Department of Pediatrics, University of Rochester School of Medicine and 
      Dentistry, Rochester, New York 14642, USA. caroline_hall@urmc.rochester.edu
FAU - Caserta, Mary T
AU  - Caserta MT
FAU - Schnabel, Kenneth C
AU  - Schnabel KC
FAU - Shelley, Lynne M
AU  - Shelley LM
FAU - Carnahan, Jennifer A
AU  - Carnahan JA
FAU - Marino, Andrea S
AU  - Marino AS
FAU - Yoo, Christina
AU  - Yoo C
FAU - Lofthus, Geraldine K
AU  - Lofthus GK
LA  - eng
GR  - 5 MO1 RR00044/RR/NCRR NIH HHS/United States
GR  - M01 RR000044/RR/NCRR NIH HHS/United States
GR  - R01 HD044430/HD/NICHD NIH HHS/United States
GR  - M01 RR000044-430762/RR/NCRR NIH HHS/United States
GR  - R01 HD 44430-01/HD/NICHD NIH HHS/United States
GR  - R01 HD044430-01/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
SB  - IM
MH  - Child, Preschool
MH  - Female
MH  - Herpesvirus 6, Human/*genetics
MH  - Humans
MH  - Infant
MH  - *Infectious Disease Transmission, Vertical
MH  - *Maternal-Fetal Exchange
MH  - Polymerase Chain Reaction
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/genetics/*virology
MH  - Roseolovirus Infections/congenital/genetics/transmission/*virology
MH  - *Virus Integration
PMC - PMC2811319
MID - NIHMS163795
EDAT- 2010/01/22 06:00
MHDA- 2010/03/10 06:00
PMCR- 2011/02/15
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
PHST- 2011/02/15 00:00 [pmc-release]
AID - 10.1086/650495 [doi]
PST - ppublish
SO  - J Infect Dis. 2010 Feb 15;201(4):505-7. doi: 10.1086/650495.