PMID- 20089725
OWN - NLM
STAT- MEDLINE
DCOM- 20100330
LR  - 20230318
IS  - 1938-3207 (Electronic)
IS  - 0002-9165 (Print)
IS  - 0002-9165 (Linking)
VI  - 91
IP  - 3
DP  - 2010 Mar
TI  - Dietary predictors of the insulin-like growth factor system in adolescent 
      females: results from the Dietary Intervention Study in Children (DISC).
PG  - 643-50
LID - 10.3945/ajcn.2009.28205 [doi]
AB  - BACKGROUND: The insulin-like growth factor (IGF) system is associated with the 
      adult diet and chronic disease. Childhood diet may influence chronic disease 
      through its effect on the IGF system; however, there is limited information 
      describing the dietary predictors of the IGF system in adolescents. OBJECTIVE: We 
      examined associations between dietary food intake [fat, protein (animal and 
      vegetable), carbohydrate, lactose, dietary fiber, calcium, zinc, and sodium] and 
      serum IGF-I, IGF binding protein 1 (IGFBP-1), IGF binding protein 3 (IGFBP-3), 
      and the IGF-I:IGFBP-3 molar ratio in adolescent females. DESIGN: One hundred 
      fifty-nine adolescent females in the Dietary Intervention Study in Children (age 
      range: 14-18 y; 0.2-6.3 y postmenarche) were included. The dietary intake was 
      assessed via three 24-h dietary recalls. IGF-related biomarkers were determined 
      by using radioimmunoassays. Associations between dietary intakes and biomarkers 
      were assessed with Pearson's correlations and multivariable linear regression. 
      Dietary intakes and biomarkers were logarithmically transformed; thus, beta 
      coefficients represented percentages. RESULTS: In analyses adjusted for energy, 
      age, and time since menarche, significant correlations (P < 0.05) were as 
      follows: IGF-I with total protein, lactose, calcium, and sodium; IGFBP-3 with 
      total fat (inverse), lactose, fiber, and calcium; IGF-I/IGFBP-3 with lactose and 
      calcium; and IGFBP-1 with vegetable protein. In multivariable analyses, 
      significant predictors of IGF-I were energy (beta = 0.14, P < 0.05) and calcium 
      (beta = 0.14, P < 0.01), the significant predictor of IGFBP-3 was calcium (beta = 
      0.07, P < 0.05), and significant predictors of IGFBP-1 were vegetable protein 
      (beta = 0.49, P < 0.05) and body mass index-for-age percentile (beta = -0.01, P < 
      0.001). CONCLUSION: This study provides evidence that dietary intake affects 
      IGF-related biomarkers-particularly elevated calcium with IGF-I and IGFBP-3 and 
      elevated vegetable protein with IGFBP-1-and, to our knowledge, is novel in 
      reporting these associations in adolescent females. The Dietary Intervention 
      Study in Children was registered at clinicaltrials.gov as NCT00000459.
FAU - Kerver, Jean M
AU  - Kerver JM
AD  - Department of Epidemiology, Michigan State University, East Lansing, MI, USA. 
      kerverje@msu.edu
FAU - Gardiner, Joseph C
AU  - Gardiner JC
FAU - Dorgan, Joanne F
AU  - Dorgan JF
FAU - Rosen, Cliff J
AU  - Rosen CJ
FAU - Velie, Ellen M
AU  - Velie EM
LA  - eng
SI  - ClinicalTrials.gov/NCT00000459
GR  - K07 CA94984/CA/NCI NIH HHS/United States
GR  - T32 HD046377/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100120
PL  - United States
TA  - Am J Clin Nutr
JT  - The American journal of clinical nutrition
JID - 0376027
RN  - 0 (Biomarkers)
RN  - 0 (Calcium, Dietary)
RN  - 0 (Dietary Proteins)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 1)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 0 (Plant Proteins)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adolescent
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Calcium, Dietary/*administration & dosage
MH  - *Diet
MH  - Diet Records
MH  - Dietary Proteins/*administration & dosage
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 1/*blood
MH  - Insulin-Like Growth Factor Binding Protein 3/*blood
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Linear Models
MH  - Plant Proteins/*administration & dosage
PMC - PMC2824156
EDAT- 2010/01/22 06:00
MHDA- 2010/03/31 06:00
PMCR- 2011/03/01
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/03/31 06:00 [medline]
PHST- 2011/03/01 00:00 [pmc-release]
AID - S0002-9165(23)01676-3 [pii]
AID - 28205 [pii]
AID - 10.3945/ajcn.2009.28205 [doi]
PST - ppublish
SO  - Am J Clin Nutr. 2010 Mar;91(3):643-50. doi: 10.3945/ajcn.2009.28205. Epub 2010 
      Jan 20.