PMID- 20091308
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20211020
IS  - 1432-2323 (Electronic)
IS  - 0364-2313 (Linking)
VI  - 34
IP  - 4
DP  - 2010 Apr
TI  - Effect of transoral incisionless fundoplication on symptoms, PPI use, and 
      ph-impedance refluxes of GERD patients.
PG  - 750-7
LID - 10.1007/s00268-010-0394-7 [doi]
AB  - BACKGROUND: Three previous studies from the same institution have reported that 
      transoral incisionless fundoplication (TIF) with the EsophyX device is effective 
      for creating a continent gastroesophageal valve and for good functional results 
      as measured only by pH-metry in patients with gastroesophageal reflux disease 
      (GERD). The objective of the present study was to evaluate the effect of TIF on 
      symptoms, use of proton pump inhibitors (PPI), esophageal motility, and 
      pH-impedance in patients with symptomatic GERD. METHODS: Twenty consecutive 
      patients were enrolled to complete the GERD-HRQL and GERD-QUAL questionnaires 
      while on and off PPI. They were also examined by upper gastrointestinal (GI) 
      endoscopy to determine Hill grade and Jobe length of the gastroesophageal valve, 
      and to check for hiatal hernia and esophagitis, esophageal manometry, and 
      pH-impedance before and 6 months after TIF. RESULTS: Six months after TIF, the 
      GERD-HRLQ and GERD-QUAL scores off-PPI therapy and the number of total and acid 
      pH-impedance refluxes were significantly reduced (p < 0.05). The PPI had been 
      completely stopped in 55% of the patient and was reduced in 22% of the patients. 
      CONCLUSIONS: At 6-month follow-up, TIF performed using the EsophyX device reduces 
      symptoms and pH-impedance refluxes, allowing interruption or reduction of PPI use 
      in 78% of patients with GERD.
FAU - Testoni, Pier Alberto
AU  - Testoni PA
AD  - Division of Gastroenterology and Gastrointestinal Endoscopy, San Raffaele 
      Scientific Institute, Vita-Salute San Raffaele University, via Olgettina 58, 
      20132, Milan, Italy. testoni.pieralberto@hsr.it
FAU - Corsetti, Maura
AU  - Corsetti M
FAU - Di Pietro, Salvatore
AU  - Di Pietro S
FAU - Castellaneta, Antonio Gianluca
AU  - Castellaneta AG
FAU - Vailati, Cristian
AU  - Vailati C
FAU - Masci, Enzo
AU  - Masci E
FAU - Passaretti, Sandro
AU  - Passaretti S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Surg
JT  - World journal of surgery
JID - 7704052
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Esophageal pH Monitoring
MH  - Female
MH  - Fundoplication/*methods
MH  - Gastric Emptying
MH  - Gastroesophageal Reflux/drug therapy/physiopathology/*surgery
MH  - Humans
MH  - Male
MH  - Manometry
MH  - Middle Aged
MH  - Proton Pump Inhibitors/*administration & dosage
MH  - Quality of Life
MH  - Statistics, Nonparametric
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
EDAT- 2010/01/22 06:00
MHDA- 2010/06/11 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - 10.1007/s00268-010-0394-7 [doi]
PST - ppublish
SO  - World J Surg. 2010 Apr;34(4):750-7. doi: 10.1007/s00268-010-0394-7.