PMID- 20092902
OWN - NLM
STAT- MEDLINE
DCOM- 20100628
LR  - 20221207
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 88
IP  - 1
DP  - 2010 Apr
TI  - Impact of ENPP1 and MMP3 gene polymorphisms on aortic calcification in patients 
      with type 2 diabetes in a Korean population.
PG  - 87-96
LID - 10.1016/j.diabres.2010.01.002 [doi]
AB  - AIMS: We investigated whether gene polymorphisms of Ecto-nucleotide 
      pyrophosphatase/phosphodiesterase 1 (ENPP1) and matrix metalloproteinase 3 (MMP3) 
      are associated with increased vascular calcification in patients with type 2 
      diabetes (T2D) and evaluated whether serum MMP3 and osteoprotegerin (OPG) levels 
      are related to calcification. METHODS: This study included 464 subjects: 269 
      patients with T2D and 195 healthy controls in South Korea. We genotyped subjects 
      for four single nucleotide polymorphisms (SNPs): ENPP1 K121Q, ENPP1 A/G+1044TGA, 
      MMP3 -709A>G and MMP3 -1475G>A. The presence or absence of calcifications in the 
      aortic arch was assessed by plain chest radiography. RESULTS: The SNPs ENPP1 
      K121Q and MMP3 -709A>G showed significant associations with T2D (P=0.001 and 
      P=0.004). The SNP ENPP1 K121Q showed a significant association with aortic arch 
      calcification in T2D (P=0.036). Serum OPG levels were significantly higher in T2D 
      patients than in the control group (P<0.001). However, serum MMP3 levels were 
      significantly lower in T2D patients than in the control group (P<0.001). 
      CONCLUSIONS: Our study demonstrates that the ENPP1 K121Q and MMP3 -709A>G 
      polymorphisms are associated with T2D, and that the ENPP1 Q allele is associated 
      with increased aortic arch calcification in a Korean population.
FAU - Lee, Jung-Eun
AU  - Lee JE
AD  - Department of Internal Medicine, Kyungpook National University School of 
      Medicine, Daegu, South Korea.
FAU - Choi, Yeon-Kyung
AU  - Choi YK
FAU - Seo, Hyun-Ae
AU  - Seo HA
FAU - Jeon, Jae-Han
AU  - Jeon JH
FAU - Jeong, Ji-Yun
AU  - Jeong JY
FAU - Moon, Seong-Su
AU  - Moon SS
FAU - Kim, Jung-Guk
AU  - Kim JG
FAU - Kim, Bo-Wan
AU  - Kim BW
FAU - Kim, Su-Won
AU  - Kim SW
FAU - Min Yoo
AU  - Min Yoo
FAU - Kim, Joon-Young
AU  - Kim JY
FAU - Lee, In-Kyu
AU  - Lee IK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100125
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Osteoprotegerin)
RN  - EC 3.1.4.- (Phosphoric Diester Hydrolases)
RN  - EC 3.1.4.1 (ectonucleotide pyrophosphatase phosphodiesterase 1)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.6.1.- (Pyrophosphatases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Analysis of Variance
MH  - Aortic Diseases/blood/complications/*genetics
MH  - Asian People/genetics
MH  - Body Composition
MH  - Calcinosis/blood/complications/*genetics
MH  - Chi-Square Distribution
MH  - Diabetes Mellitus, Type 2/blood/complications/*genetics
MH  - Diet
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/blood/*genetics
MH  - Middle Aged
MH  - Osteoprotegerin/blood
MH  - Phosphoric Diester Hydrolases/*genetics
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Pyrophosphatases/*genetics
MH  - Regression Analysis
MH  - Republic of Korea
EDAT- 2010/01/23 06:00
MHDA- 2010/06/29 06:00
CRDT- 2010/01/23 06:00
PHST- 2009/09/16 00:00 [received]
PHST- 2009/12/17 00:00 [revised]
PHST- 2010/01/04 00:00 [accepted]
PHST- 2010/01/23 06:00 [entrez]
PHST- 2010/01/23 06:00 [pubmed]
PHST- 2010/06/29 06:00 [medline]
AID - S0168-8227(10)00003-3 [pii]
AID - 10.1016/j.diabres.2010.01.002 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2010 Apr;88(1):87-96. doi: 
      10.1016/j.diabres.2010.01.002. Epub 2010 Jan 25.