PMID- 20093332
OWN - NLM
STAT- MEDLINE
DCOM- 20100325
LR  - 20220408
IS  - 1477-111X (Electronic)
IS  - 0267-6591 (Linking)
VI  - 24
IP  - 6
DP  - 2009 Nov
TI  - The use of autologous platelet gel (APG) for high-risk patients in cardiac 
      surgery -- is it beneficial?
PG  - 381-7
LID - 10.1177/0267659109358283 [doi]
AB  - BACKGROUND: Wound healing in cardiac surgery has become a major problem due to 
      the impaired risk profile of many patients. The aim of this study was to prove 
      the influence of autologous platelet gel (APG) on wound healing in a special 
      group of high-risk patients undergoing coronary surgery. PATIENTS AND METHODS: We 
      performed a prospective, double-blind study in 44 patients with a special risk 
      constellation relating to wound complications (obesity, diabetes, smoker, New 
      York Heart Association (NYHA) III-IV and peripheral vascular disease). The study 
      group was treated with APG, prepared using the Magellan platelet separator, the 
      control group underwent conventional wound treatment. RESULTS: The incidence of 
      major and minor wound complications at the thoracotomy, as well as in the area of 
      saphenous vein harvesting, was not pronounced in either of the groups. Blood loss 
      and pain sensations did not differ significantly either. Stay in the intensive 
      care unit (ICU) and the in-hospital mortality were also comparable. The duration 
      of the entire operation and the time until removing the chest-tubes were 
      prolonged in the study group. CONCLUSION: Despite promising results in other 
      fields of surgery, APG shows no beneficial effect in high-risk patients 
      undergoing cardiac surgery. Probably, it depends on different types of 
      microcirculation in atherosclerotic patients, which are quite different from 
      those of other surgical areas. This factor may offset the existing beneficial 
      platelet effects which could be observed, for example, in maxillo-facial surgery.
FAU - Litmathe, Jens
AU  - Litmathe J
AD  - Department of Thoracic- and Cardiovascular Surgery, Heinrich-Heine-University, 
      Moorenstrasse 5, D-40225 Duesseldorf, Germany. jens-litmathe@t-online.de
FAU - Philipp, Christian
AU  - Philipp C
FAU - Kurt, Muhammed
AU  - Kurt M
FAU - Boeken, Udo
AU  - Boeken U
FAU - Gams, Emmeran
AU  - Gams E
FAU - Feindt, Peter
AU  - Feindt P
LA  - eng
PT  - Journal Article
PL  - England
TA  - Perfusion
JT  - Perfusion
JID - 8700166
RN  - 0 (Gels)
SB  - IM
MH  - Aged
MH  - Blood Platelets/*metabolism
MH  - *Cardiac Surgical Procedures
MH  - Cohort Studies
MH  - Gels/*therapeutic use
MH  - Humans
MH  - Middle Aged
MH  - Risk Factors
MH  - *Wound Healing
EDAT- 2010/01/23 06:00
MHDA- 2010/03/26 06:00
CRDT- 2010/01/23 06:00
PHST- 2010/01/23 06:00 [entrez]
PHST- 2010/01/23 06:00 [pubmed]
PHST- 2010/03/26 06:00 [medline]
AID - 24/6/381 [pii]
AID - 10.1177/0267659109358283 [doi]
PST - ppublish
SO  - Perfusion. 2009 Nov;24(6):381-7. doi: 10.1177/0267659109358283.