PMID- 20093938
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20211020
IS  - 1542-233X (Electronic)
IS  - 1542-2321 (Print)
IS  - 1542-2321 (Linking)
VI  - 36
IP  - 2
DP  - 2010 Mar
TI  - Entire contact lens imaged in vivo and in vitro with spectral domain optical 
      coherence tomography.
PG  - 73-6
LID - 10.1097/ICL.0b013e3181d0423e [doi]
AB  - OBJECTIVES: To demonstrate the capability of directly visualizing the entire 
      ocular surface and the entire contact lens on the eye using spectral domain 
      optical coherence tomography (SD-OCT). METHODS: A custom-built, high-speed, and 
      high-resolution SD-OCT was developed with extended scan depth and width. The eye 
      was imaged before and after wearing a toric soft contact lens (PureVision; Bausch 
      & Lomb). A lubricant eye drop (Soothe; Bausch & Lomb) was instilled in the eye to 
      enhance the image contrast on the lens. The same toric soft contact lens immersed 
      in the contact lens solution was also imaged with a contrast enhancement medium 
      (0.5% Intralipid). RESULTS: Cross-sectional OCT images of the entire ocular 
      surface were acquired with high-resolution 2,048 x 2,048 pixels. Quantitative 
      surface height map of the ocular surface was obtained from a radial scan data set 
      containing 32 B-scans. With the contrast enhancement agent, the entire toric soft 
      contact lens was clearly visualized, both in vitro and on the eye. The surfaces 
      of the lens were detected and used to generate the thickness maps of the soft 
      contact lens. CONCLUSIONS: Spectral domain optical coherence tomography with 
      extended scan depth and width is a promising tool for imaging the entire ocular 
      surface shape and soft contact lenses. This successful demonstration suggests 
      that the extended depth SD-OCT is effective in studying ocular surface shape and 
      its interaction with a soft contact lens. The novel method is helpful for the 
      evaluation of contact lens fitting and lens design.
FAU - Shen, Meixiao
AU  - Shen M
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, 
      Miami, Florida 33136, USA.
FAU - Wang, Michael R
AU  - Wang MR
FAU - Wang, Jianhua
AU  - Wang J
FAU - Yuan, Yimin
AU  - Yuan Y
FAU - Chen, Feng
AU  - Chen F
LA  - eng
GR  - P30 EY014801/EY/NEI NIH HHS/United States
GR  - R03 EY016420-03/EY/NEI NIH HHS/United States
GR  - R03 EY016420-02/EY/NEI NIH HHS/United States
GR  - R03 EY016420/EY/NEI NIH HHS/United States
GR  - R03 EY016420-01/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Eye Contact Lens
JT  - Eye & contact lens
JID - 101160941
RN  - 0 (Contact Lens Solutions)
RN  - 0 (Contrast Media)
RN  - 0 (Fat Emulsions, Intravenous)
SB  - IM
MH  - Contact Lens Solutions
MH  - *Contact Lenses, Hydrophilic
MH  - Contrast Media
MH  - Eye/*anatomy & histology
MH  - Fat Emulsions, Intravenous
MH  - Humans
MH  - In Vitro Techniques
MH  - Tomography, Optical Coherence/*methods
PMC - PMC2881326
MID - NIHMS198700
EDAT- 2010/01/23 06:00
MHDA- 2010/06/04 06:00
PMCR- 2011/03/01
CRDT- 2010/01/23 06:00
PHST- 2010/01/23 06:00 [entrez]
PHST- 2010/01/23 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
PHST- 2011/03/01 00:00 [pmc-release]
AID - 10.1097/ICL.0b013e3181d0423e [doi]
PST - ppublish
SO  - Eye Contact Lens. 2010 Mar;36(2):73-6. doi: 10.1097/ICL.0b013e3181d0423e.