PMID- 20095908
OWN - NLM
STAT- MEDLINE
DCOM- 20120410
LR  - 20100222
IS  - 1931-843X (Electronic)
IS  - 1540-9996 (Linking)
VI  - 19
IP  - 2
DP  - 2010 Feb
TI  - Estrogen receptor-1 genetic polymorphisms for the risk of premature ovarian 
      failure and early menopause.
PG  - 297-304
LID - 10.1089/jwh.2008.1317 [doi]
AB  - BACKGROUND: The aim of this study was to investigate the role of the estrogen 
      receptor 1 (ESR1) genetic polymorphisms for early menopause that was classified 
      as premature ovarian failure (POF) and early menopause (EM) and to examine 
      whether the associations of ESR1 genetic variants are different for POF and EM. 
      METHODS: We selected 100 POF cases and matched 100 EM cases and 200 normal 
      menopause (NM) controls from the Korean Multi-Center Cohort. Among them, we 
      restricted idiopathic POF and EM cases vs NM controls by excluding POF/EM cases 
      with medical/surgical causes. The XbaI (rs9340799) and PvuII (rs2234693) in the 
      ESR1 gene were genotyped. The single-nucleotide polymorphism (SNP) and haplotype 
      effects were analyzed by multivariate logistic regression and haplotype analysis. 
      Also nominal polytomous logistic regression was used to find whether ESR1 genetic 
      variants are differently associated with POF and EM. RESULTS: The global p values 
      for idiopathic POF and EM were 0.08 and 0.39 (SNP-based), and <0.001 and 0.12 
      (haplotype-based), respectively. The XbaI genetic variant containing the X allele 
      was marginally significantly associated with a reduced risk of idiopathic POF (OR 
      = 0.6, 95% CI 0.3-1.0). The P-x haplotype and diplotypes significantly decreased 
      the risk of idiopathic POF (OR = 0.5, 95% CI 0.2-0.9; OR = 0.4, 95% CI 0.2-0.9, 
      respectively). In contrast from POF, the P-x haplotypes and diplotypes 
      insignificantly increased the risk for both idiopathic EM (p(polytomous) = 0.009 
      for P-x haplotype; p(polytomous) = 0.02 for P-x diplotypes). CONCLUSION: Our 
      results suggest that the ESR1 gene including PvuII and XbaI polymorphisms may 
      modify the risk of idiopathic premature ovarian failure (POF) but not idiopathic 
      early menopause (EM) risk.
FAU - Yang, Jae Jeong
AU  - Yang JJ
AD  - Department of Preventive Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Cho, Lisa Y
AU  - Cho LY
FAU - Lim, Yun Jeong
AU  - Lim YJ
FAU - Ko, Kwang-Pil
AU  - Ko KP
FAU - Lee, Kun-Sei
AU  - Lee KS
FAU - Kim, Hyeongsu
AU  - Kim H
FAU - Yim, Sung Vin
AU  - Yim SV
FAU - Chang, Soung Hoon
AU  - Chang SH
FAU - Park, Sue K
AU  - Park SK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Womens Health (Larchmt)
JT  - Journal of women's health (2002)
JID - 101159262
RN  - 0 (Estrogen Receptor alpha)
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Estrogen Receptor alpha/*genetics
MH  - Female
MH  - Humans
MH  - Menopause, Premature/*genetics
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Primary Ovarian Insufficiency/*genetics
MH  - Prospective Studies
MH  - Republic of Korea
MH  - Risk
EDAT- 2010/01/26 06:00
MHDA- 2012/04/11 06:00
CRDT- 2010/01/26 06:00
PHST- 2010/01/26 06:00 [entrez]
PHST- 2010/01/26 06:00 [pubmed]
PHST- 2012/04/11 06:00 [medline]
AID - 10.1089/jwh.2008.1317 [doi]
PST - ppublish
SO  - J Womens Health (Larchmt). 2010 Feb;19(2):297-304. doi: 10.1089/jwh.2008.1317.