PMID- 20096176
OWN - NLM
STAT- MEDLINE
DCOM- 20100824
LR  - 20140730
IS  - 1699-7980 (Electronic)
IS  - 0210-4806 (Linking)
VI  - 33
IP  - 10
DP  - 2009 Nov
TI  - Impact of surgical delay on pathological findings and prognosis of patients with 
      prostate cancer.
PG  - 1069-77
AB  - PURPOSE: To determine if a delay between prostate biopsy (PB) and radical 
      prostatectomy (RP) has an impact on pathological findings and prognosis of 
      prostate cancer patients (PCa). MATERIAL AND METHODS: Patients (n = 232) who 
      underwent RP, with at least two postoperative PSA readings. DESIGN: retrospective 
      observational cohort study. PERIOD: May 2000-March 2007. Delay was defined as 
      time in months between PB and RP. STATISTICAL ANALYSIS: delay was analysed as a 
      continuous variable or else categorised according to the median (6 months). A 
      multivariate logistic regression analysis was performed to define variables 
      associated with extracapsular disease. Biochemical recurrence-free survival 
      (BRFS) was studied using the Kaplan-Meier method and multivariate Cox 
      proportional hazards analysis. RESULTS: Differences between delay groups < or = 
      and > 6 months were significant only with regards to age (p = 0.041), considering 
      both groups as comparable. Differences between groups related to pathological 
      variables were not observed in any case. Mean followup was not significantly 
      different between both groups (p = 0.112). The probability of extracapsular 
      disease varied significantly depending on PSA, biopsy Gleason score and the 
      percentage of positive cores, while multivariate analysis found no relationship 
      with delay. Biochemical relapse was detected in 39 cases (16.81%). BRFS in delay 
      < or = 6 months group was 86.1%, 78.4%, 78.4% and 78.4% at 1, 2, 5 and 7 years, 
      while BRFS in delay > 6 months group was 88.9%, 82.8%, 77.4%, 77.4% and 77.4% at 
      1, 2, 5 and 7 years (p = 0.632). Delay was not associated with BRFS in 
      multivariate analysis; only the percentage of positive cores independently 
      predicted BRFS. In patients with high-grade PCa, percentage of positive cores was 
      the only independent variable to predict extracapsular disease and BRFS. Delay 
      was not associated with extracapsular disease or BRFS. CONCLUSIONS: Reasonable 
      surgical delay does not cause a significant negative impact on pathological 
      findings of RP specimens, nor in the BRFS of patients with localized PCa.
FAU - Rodriguez Alonso, Andres
AU  - Rodriguez Alonso A
AD  - Urology Department, Arquitecto Marcide Hospital, Ferrol, La Coruna, Spain. 
      arodri68@gmail.com
FAU - Gonzalez Blanco, Alfonso
AU  - Gonzalez Blanco A
FAU - Pita Fernandez, Salvador
AU  - Pita Fernandez S
FAU - Pertega Diaz, Sonia
AU  - Pertega Diaz S
FAU - Bonelli Martin, Carlos
AU  - Bonelli Martin C
FAU - Cuerpo Perez, Miguel A
AU  - Cuerpo Perez MA
LA  - eng
LA  - spa
PT  - Journal Article
PL  - Spain
TA  - Actas Urol Esp
JT  - Actas urologicas espanolas
JID - 7704993
SB  - IM
MH  - Aged
MH  - Biopsy
MH  - Cohort Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prostatectomy
MH  - Prostatic Neoplasms/*pathology/*surgery
MH  - Retrospective Studies
MH  - Time Factors
EDAT- 2010/01/26 06:00
MHDA- 2010/08/25 06:00
CRDT- 2010/01/26 06:00
PHST- 2010/01/26 06:00 [entrez]
PHST- 2010/01/26 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
AID - 13146548 [pii]
PST - ppublish
SO  - Actas Urol Esp. 2009 Nov;33(10):1069-77.