PMID- 20096353
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20240312
IS  - 1873-3913 (Electronic)
IS  - 0898-6568 (Print)
IS  - 0898-6568 (Linking)
VI  - 22
IP  - 7
DP  - 2010 Jul
TI  - Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and 
      dysfunction.
PG  - 977-83
LID - 10.1016/j.cellsig.2010.01.010 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory molecule, 
      which upon engagement with its cognate receptors on target cells, triggers 
      downstream signaling cascades that control a number of cellular processes related 
      to cell viability, gene expression, ion homeostasis, and synaptic integrity. In 
      the central nervous system (CNS), TNF-alpha is produced by brain-resident 
      astrocytes, microglia, and neurons in response to numerous intrinsic and 
      extrinsic stimuli. This review will summarize the key events that lead to 
      TNF-alpha elaboration in the CNS, and the effects that these inflammatory signals 
      impart on neuronal signaling in the context of homeostasis and neuropathology.
CI  - (c) 2010 Elsevier Inc. All rights reserved.
FAU - Park, Keigan M
AU  - Park KM
AD  - Department of Pharmacology and Physiology, University of Rochester Medical 
      Center, Rochester, NY 14642, USA.
FAU - Bowers, William J
AU  - Bowers WJ
LA  - eng
GR  - F31 NS056731-03/NS/NINDS NIH HHS/United States
GR  - R01 AG026328/AG/NIA NIH HHS/United States
GR  - R01 AG026328-03/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20100121
PL  - England
TA  - Cell Signal
JT  - Cellular signalling
JID - 8904683
RN  - 0 (Ion Channels)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Alzheimer Disease/etiology
MH  - Animals
MH  - Brain/embryology
MH  - Cell Survival
MH  - Homeostasis
MH  - Humans
MH  - Ion Channels/metabolism
MH  - Mice
MH  - Neuronal Plasticity
MH  - Neurons/*metabolism
MH  - Parkinson Disease/etiology
MH  - *Signal Transduction
MH  - Tumor Necrosis Factor-alpha/*physiology
PMC - PMC2860549
MID - NIHMS170300
EDAT- 2010/01/26 06:00
MHDA- 2010/06/11 06:00
PMCR- 2011/07/01
CRDT- 2010/01/26 06:00
PHST- 2009/12/31 00:00 [received]
PHST- 2010/01/13 00:00 [accepted]
PHST- 2010/01/26 06:00 [entrez]
PHST- 2010/01/26 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
PHST- 2011/07/01 00:00 [pmc-release]
AID - S0898-6568(10)00017-3 [pii]
AID - 10.1016/j.cellsig.2010.01.010 [doi]
PST - ppublish
SO  - Cell Signal. 2010 Jul;22(7):977-83. doi: 10.1016/j.cellsig.2010.01.010. Epub 2010 
      Jan 21.