PMID- 20097112
OWN - NLM
STAT- MEDLINE
DCOM- 20100802
LR  - 20111117
IS  - 1878-1780 (Electronic)
IS  - 1262-3636 (Linking)
VI  - 36
IP  - 2
DP  - 2010 Apr
TI  - Dietary cassava, beta-cell function and hyperbolic product loss rate in type 2 
      diabetes patients from South Kivu.
PG  - 108-13
LID - 10.1016/j.diabet.2009.08.001 [doi]
AB  - OBJECTIVE: Cassava, a major carbohydrate source in Africa, contains potentially 
      diabetogenic chemicals, although its consumption is not associated with incident 
      diabetes. As it is not known whether cassava intake impairs residual beta-cell 
      function in patients with type 2 diabetes (T2D), our study compared the metabolic 
      phenotypes of diet- and/or oral antidiabetic drug (OAD)-treated T2D patients in 
      South Kivu (Democratic Republic of the Congo) with [Cassava (+); n=147] and 
      without [Cassava (-); n=46] self-reported cassava consumption. DESIGN & METHODS: 
      A total of 193 patients [male:female (%) 37:63; mean +/-1 SD age: 56+/-11 years] 
      were interviewed to determine the frequency and distribution of eight major 
      dietary carbohydrate (CHO) sources (cassava, plantain, rice, maize, bread, 
      sorghum, potatoes and legumes). Fasting glucose, insulin and lipid levels were 
      obtained after an overnight fast and OAD discontinuation. Cassava (+) and Cassava 
      (-) groups were compared for HOMA indices of insulin sensitivity (S), beta-cell 
      function (B), hyperbolic product (B x S) and B x S loss rate (B x S LR). RESULTS: 
      Diabetes duration was 6+/-7 years, age at diabetes diagnosis was 51+/-11 years 
      and BMI was 25+/-5 kg/m(2). Cassava intake was reported by 76% of patients, and 
      amounted to 29+/-11% of their daily CHO intake. The Cassava (-) group ate more 
      plantain, maize, bread and potatoes, and less sorghum. Age, gender and age at 
      diabetes diagnosis did not differ between Cassava (+) and (-) patients, nor did 
      BMI, fat mass, waist circumference, lipid profile and metabolic syndrome 
      prevalence. HOMA indices of S, B, B x S and B x S LR did not differ significantly 
      between groups-Cassava (+) vs (-): S, 114+/-56% vs 114+/-60%; B, 34+/-30% vs 
      39+/-32%; B x S, 38+/-35% vs 40+/-31%; and B x S LR, 1.19+/-0.84% vs 1.09+/-0.65% 
      per year-nor did the glucose-lowering modalities. CONCLUSION: Cassava consumption 
      in South Kivu is not associated with changes in T2D phenotype or in the glucose 
      homoeostasis determinants S, B, B x S and B x S LR. Cassava consumption does not 
      accelerate beta-cell function loss in such a population, whose markedly 
      compromised glucose homoeostasis renders them vulnerable to environmentally 
      acquired beta-cell impairment.
CI  - (c) 2009 Elsevier Masson SAS. All rights reserved.
FAU - Manwa, B
AU  - Manwa B
AD  - Universite catholique de Bukavu, Congo, RDC.
FAU - Kashongwe, Z
AU  - Kashongwe Z
FAU - Bahindwa, B
AU  - Bahindwa B
FAU - Kolanowski, J
AU  - Kolanowski J
FAU - Hermans, M P
AU  - Hermans MP
LA  - eng
PT  - Journal Article
DEP - 20100122
PL  - France
TA  - Diabetes Metab
JT  - Diabetes & metabolism
JID - 9607599
RN  - 0 (Insulin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Carbohydrate Metabolism/physiology
MH  - Cross-Sectional Studies
MH  - Democratic Republic of the Congo/epidemiology
MH  - Diabetes Mellitus, Type 2/drug therapy/epidemiology/*metabolism
MH  - *Diet
MH  - Female
MH  - Humans
MH  - Insulin/metabolism
MH  - Insulin-Secreting Cells/physiology
MH  - Male
MH  - *Manihot
MH  - Middle Aged
MH  - Phenotype
EDAT- 2010/01/26 06:00
MHDA- 2010/08/03 06:00
CRDT- 2010/01/26 06:00
PHST- 2008/12/29 00:00 [received]
PHST- 2009/08/31 00:00 [revised]
PHST- 2009/08/31 00:00 [accepted]
PHST- 2010/01/26 06:00 [entrez]
PHST- 2010/01/26 06:00 [pubmed]
PHST- 2010/08/03 06:00 [medline]
AID - S1262-3636(09)00256-0 [pii]
AID - 10.1016/j.diabet.2009.08.001 [doi]
PST - ppublish
SO  - Diabetes Metab. 2010 Apr;36(2):108-13. doi: 10.1016/j.diabet.2009.08.001. Epub 
      2010 Jan 22.