PMID- 20097244
OWN - NLM
STAT- MEDLINE
DCOM- 20100903
LR  - 20100319
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 71
IP  - 4
DP  - 2010 Apr
TI  - MICA polymorphism in a northern Chinese Han population: The identification of a 
      new MICA allele, MICA*059.
PG  - 423-7
LID - 10.1016/j.humimm.2010.01.025 [doi]
AB  - The major histocompatibility complex class I chain-related gene A (MICA) in 
      humans, located 46 kb centromeric to human leukocyte antigen (HLA)-B, is highly 
      polymorphic. In addition to its primary role in immune surveillance, recent data 
      highlight the importance of MICA in organ transplantation and in susceptibility 
      to some diseases. In this study, 104 healthy, unrelated Han subjects recruited 
      from central Inner Mongolia Autonomous Region, northern China, were investigated 
      by sequence-based typing and fragment analysis for MICA allelic variation, 
      MICA-HLA-B linkage disequilibrium, and HLA-A-Cw-B-MICA haplotypic diversity. 
      Nineteen MICA alleles were observed, the most frequent of which were MICA*00801, 
      MICA*010, MICA*00201, MICA*00901, and MICA*045, with gene frequencies of 23.08%, 
      18.75%, 12.02%, 12.02%, and 8.17%, respectively. The peculiarity in HLA-B-MICA 
      haplotypic configurations was also uncovered. In particular, there was a 
      clear-cut dichotomy between MICA*00801 and MICA*045 in their linkage to members 
      of HLA-B*13 lineage, which was frequently represented in this population. A new 
      MICA allele, MICA*059, was identified, which appeared to be evolutionarily linked 
      to MICA*045. Haplotype HLA-A*30-Cw*06-B*1302-MICA*00801, previously not reported 
      in other populations, was found with a frequency of 8.65% in this population. Our 
      results provide new data about MICA genetic polymorphism in Chinese Han 
      populations, which will form the basis for future studies of the potential role 
      of MICA in allogeneic organ transplantation and disease susceptibility in related 
      ethnic groups.
FAU - Tian, Wei
AU  - Tian W
AD  - Department of Immunology, Central South University, Changsha, Hunan, People's 
      Republic of China. tianwei3@yahoo.com
FAU - Cai, Jin H
AU  - Cai JH
FAU - Wang, Fan
AU  - Wang F
FAU - Li, Li X
AU  - Li LX
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100206
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
SB  - IM
MH  - *Alleles
MH  - China
MH  - DNA Mutational Analysis
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Graft Rejection/*genetics/immunology
MH  - HLA Antigens/*genetics
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Linkage Disequilibrium
MH  - *Organ Transplantation
MH  - Polymorphism, Genetic
EDAT- 2010/01/26 06:00
MHDA- 2010/09/04 06:00
CRDT- 2010/01/26 06:00
PHST- 2009/10/02 00:00 [received]
PHST- 2009/12/28 00:00 [revised]
PHST- 2010/01/15 00:00 [accepted]
PHST- 2010/01/26 06:00 [entrez]
PHST- 2010/01/26 06:00 [pubmed]
PHST- 2010/09/04 06:00 [medline]
AID - S0198-8859(10)00035-2 [pii]
AID - 10.1016/j.humimm.2010.01.025 [doi]
PST - ppublish
SO  - Hum Immunol. 2010 Apr;71(4):423-7. doi: 10.1016/j.humimm.2010.01.025. Epub 2010 
      Feb 6.