PMID- 20097272
OWN - NLM
STAT- MEDLINE
DCOM- 20100601
LR  - 20221207
IS  - 1873-2747 (Electronic)
IS  - 0361-9230 (Linking)
VI  - 81
IP  - 6
DP  - 2010 Apr 5
TI  - Interleukin-18 promoter polymorphisms and risk of ischemic stroke.
PG  - 590-4
LID - 10.1016/j.brainresbull.2010.01.008 [doi]
AB  - Ischemic stroke (IS) is a major cause of morbidity and mortality around the 
      world. Interleukin-18 (IL-18) plays an important role in the pathogenesis of IS 
      and IL-18 promoter polymorphisms have been shown to be associated with levels of 
      expression of IL-18. We investigated the association of two functional 
      polymorphisms in IL-18 promoter, -607C/A (rs1946518) and -137G/C (rs187238), with 
      the risk of ischemic stroke in a Han Chinese population of 423 patients and 384 
      healthy controls matched for sex and age. The results revealed that the -607C 
      allele was associated with an increased risk of IS with an odds ratios (OR) of 
      1.358 (P = 0.002, power = 100%) and the presence of the -137G allele was 
      correlated with increased the risk of IS in the subtype of patients with large 
      artery atherosclerosis (LAA) (OR = 1.583, P = 0.02, power = 94%). Patients with 
      the -607C/-137G haplotype also had significantly increased risk of IS compared to 
      controls (OR = 1.341, P = 0.005, power = 100%). Our findings suggest that these 
      functional polymorphisms in the IL-18 promoter are involved in development of IS 
      in the Han Chinese population.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Zhang, Na
AU  - Zhang N
AD  - Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao 
      University, Qingdao, Shandong Province 266071, China.
FAU - Yu, Jin-Tai
AU  - Yu JT
FAU - Yu, Nan-Nan
AU  - Yu NN
FAU - Lu, Rui-Chun
AU  - Lu RC
FAU - Ma, Teng
AU  - Ma T
FAU - Wang, Nai-Dong
AU  - Wang ND
FAU - Miao, Dan
AU  - Miao D
FAU - Song, Jing-Hui
AU  - Song JH
FAU - Tan, Lan
AU  - Tan L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100125
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Asian People/genetics
MH  - Atherosclerosis/genetics
MH  - Brain Ischemia/*genetics
MH  - China
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Male
MH  - Point Mutation
MH  - *Polymorphism, Genetic
MH  - *Promoter Regions, Genetic
MH  - Risk
MH  - Stroke/*genetics
EDAT- 2010/01/26 06:00
MHDA- 2010/06/02 06:00
CRDT- 2010/01/26 06:00
PHST- 2009/10/26 00:00 [received]
PHST- 2010/01/10 00:00 [revised]
PHST- 2010/01/14 00:00 [accepted]
PHST- 2010/01/26 06:00 [entrez]
PHST- 2010/01/26 06:00 [pubmed]
PHST- 2010/06/02 06:00 [medline]
AID - S0361-9230(10)00027-4 [pii]
AID - 10.1016/j.brainresbull.2010.01.008 [doi]
PST - ppublish
SO  - Brain Res Bull. 2010 Apr 5;81(6):590-4. doi: 10.1016/j.brainresbull.2010.01.008. 
      Epub 2010 Jan 25.