PMID- 20097447
OWN - NLM
STAT- MEDLINE
DCOM- 20120808
LR  - 20131121
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 32
IP  - 12
DP  - 2011 Dec
TI  - Increased D-aspartate brain content rescues hippocampal age-related synaptic 
      plasticity deterioration of mice.
PG  - 2229-43
LID - 10.1016/j.neurobiolaging.2010.01.002 [doi]
AB  - Until recently, free d-amino acids were thought to be involved only in bacterial 
      physiology. Nevertheless, today there is evidence that D-serine, by acting as 
      co-agonist at NMDARs, plays a role in controlling neuronal functions in mammals. 
      Besides D-serine, another D-amino acid, D-aspartate (D-Asp), is found in the 
      mammalian brain with a temporal gradient of occurrence: high in embryo and low in 
      adult. In this study, we demonstrate that D-Asp acts as an endogenous NMDAR 
      agonist, since it triggers currents via interaction with each of NR2A-D receptor 
      subunits. According to its pharmacological features, we showed that oral 
      administration of D-Asp strongly enhances NMDAR-dependent LTP in adulthood and, 
      in turn, completely rescues the synaptic plasticity decay observed in the 
      hippocampus of aged animals. Therefore, our findings suggest a tantalizing 
      hypothesis for which this in-embryo-occurring D-amino acid, when "forced" over 
      its physiological content, may disclose plasticity windows inside which it 
      counteracts the age-related reduction of NMDAR signaling.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Errico, Francesco
AU  - Errico F
AD  - CEINGE Biotecnologie Avanzate, Via Comunale Margherita, 482 - 80145, Naples, 
      Italy.
FAU - Nistico, Robert
AU  - Nistico R
FAU - Napolitano, Francesco
AU  - Napolitano F
FAU - Mazzola, Carmen
AU  - Mazzola C
FAU - Astone, Dalila
AU  - Astone D
FAU - Pisapia, Teresa
AU  - Pisapia T
FAU - Giustizieri, Michela
AU  - Giustizieri M
FAU - D'Aniello, Antimo
AU  - D'Aniello A
FAU - Mercuri, Nicola B
AU  - Mercuri NB
FAU - Usiello, Alessandro
AU  - Usiello A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100125
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 4SR0Q8YD1X (D-Aspartic Acid)
SB  - IM
MH  - Aging/pathology/*physiology
MH  - Animals
MH  - Brain/metabolism/physiology
MH  - D-Aspartic Acid/metabolism/*physiology
MH  - Excitatory Postsynaptic Potentials/physiology
MH  - Exploratory Behavior/physiology
MH  - Hippocampus/pathology/*physiology
MH  - Male
MH  - Maze Learning/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neuronal Plasticity/*physiology
MH  - Synapses/parasitology/*physiology
MH  - Up-Regulation/*physiology
EDAT- 2010/01/26 06:00
MHDA- 2012/08/09 06:00
CRDT- 2010/01/26 06:00
PHST- 2009/07/31 00:00 [received]
PHST- 2010/01/04 00:00 [revised]
PHST- 2010/01/07 00:00 [accepted]
PHST- 2010/01/26 06:00 [entrez]
PHST- 2010/01/26 06:00 [pubmed]
PHST- 2012/08/09 06:00 [medline]
AID - S0197-4580(10)00031-X [pii]
AID - 10.1016/j.neurobiolaging.2010.01.002 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2011 Dec;32(12):2229-43. doi: 
      10.1016/j.neurobiolaging.2010.01.002. Epub 2010 Jan 25.